Essays about: "PD-L1"
Showing result 1 - 5 of 6 essays containing the word PD-L1.
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1. Genetic manipulation to improve efficacy of dendric cell adoptive immunotherapy against cancer in dogs
University essay from Karlstads universitetAbstract : To improve the efficacy of the dendritic cell vaccine Alv B DC from Alv B, the PD-L1 expression in cancer cells was attempted to be reduced through a transfection with a custom designed siRNA. Before transfecting the dendritic cells, the siRNA functionality had to be tested through flow cytometry, that resulted in negative results and therefore led to a RT-qPCR protocol that indicated that the siRNA was functional. READ MORE
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2. Molecular mapping of the HGSOC tumour microenvironment
University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologiAbstract : High-grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer, and its heterogeneity poses a challenge for the discovery of reliable diagnostic biomarkers, therapeutic targets, and predicting treatment response, particularly to immunotherapy. The current standard diagnostic and treatment options are inadequate, resulting in late diagnosis and poor prognosis. READ MORE
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3. Evaluating LOAd703 in combination with chemotherapeutic agents in ovarian cancer
University essay from Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Institutionen för immunologi, genetik och patologiAbstract : Ovarian cancer is a disease with a high rate of mortality where the need for novel treatments will increase in the near future as older and populous generations reach the age where the cancer is usually diagnosed. Once treated, ovarian cancer tends to recur and display a newfound resistance against the platinum-based chemotherapeutic drugs that are used to treat the disease. READ MORE
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4. Investigation Of Human Cancer Immune Interaction Using In Vitro Assays
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Cancer immunotherapy, including immune checkpoint blocking antibodies are important components for treatment of patients with various types of cancer as they enhance the ability of the immune system to fight tumours. However, tumor cells have the ability to develop resistance to a variety of transitional therapies such as chemotherapy. READ MORE
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5. Intratumoral heterogeneity in early breast cancer
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : The use of adjuvant The use of adjuvant polychemotherapy (ACT) confers unequivocal benefits in terms of relapse free (RFS) and overall survival (OS) after resection of early breast cancer (BC). Although the magnitude of benefit is the same regardless of clinicopathological factors such as ER expression or nodal stage, it is clear that a substantial proportion of patients will eventually relapse and succumb to the disease. READ MORE