Essays about: "PEGylation"

Found 5 essays containing the word PEGylation.

  1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

    Author : Elina Edidovica; [2024]
    Keywords : Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

    Abstract : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. READ MORE

  3. 2. Development of a combined In-Cell ELISA and flow cytometry method for quantification of uptake of PEGylated nanoparticles by Raw264.7 and HepG2 cells

    University essay from Lunds universitet/Tillämpad biokemi

    Author : Evelina Folkesson; [2016]
    Keywords : HepG2; Raw264.7; PEGylation; PEG; cancer; nanoparticles; In-Cell ELISA; flow cytometry; applied biochemistry; tillämpad biokemi; Technology and Engineering;

    Abstract : Cancer is one of today’s most common causes of human mortality. For long, chemotherapeutics has been a conventional treatment of the disease, but due to its low precision and high frequency of side effects, this treatment has been highly debated. READ MORE

  4. 3. Performance analysis of a PEGylation process -Process comparison of a tubular reactor with recirculation to a conventional batch reactor

    University essay from Lunds universitet/Kemiteknik (CI)

    Author : Boris Torbica; [2015]
    Keywords : Ion Exchange Chromatography; Recirculation; Tubular reactor; Tube reactor; PEGylation; PEG Polyethylene glycol; IEC; Optimisation; Chemical Engineering; kemiteknik; Technology and Engineering;

    Abstract : Since the rise of therapeutical proteins, there has been a growing interest in biopharmaceuticals over the years. Research was made to combat various protein weaknesses like fast degradation and low solubility. A discovery in the 1970s suggested that an attachment of polyethylene glycol (PEG) on protein surfaces would solve the specific problems. READ MORE

  5. 4. Optimization of a PEGylation process

    University essay from Lunds universitet/Kemiteknik (CI)

    Author : Fredrik Tegnér; [2015]
    Keywords : SERC reactor; Simulation; PEGylation; Optimization; chemical engineering; kemiteknik; Technology and Engineering;

    Abstract : The PEGylation process is a covalent attachment between a protein (the pharmaceutical) and poly ethylene glycol (PEG) and since the beginning in 1977 PEGylation processes have been used to improve pharmaceuticals. PEGylation of a pharmaceutical achieves improved properties like greater solubility in water, longer residence time in vivo and extended shelf life. READ MORE

  6. 5. Halfsphere Derivatisation of Magnetic Micro Particles

    University essay from Institutionen för biologi och kemiteknik; Akademin för hållbar samhälls- och teknikutveckling

    Author : Nadea Dilanson; [2008]
    Keywords : ;

    Abstract : Abstract   This exam project is an effort to derivatize one side of magnetic beads with one kind of molecule  , and another one on the opposite side. First the surface of the sphere is loaded with a suitable linker with, e.g. amino or hydroxyl groups. READ MORE