Essays about: "PK PD"

Showing result 1 - 5 of 9 essays containing the words PK PD.

  1. 1. Translation of pharmacometric models from NONMEM to nlmixr2 and RxODE2

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Johan Borg; [2023]
    Keywords : pharmacy; pharmacokinetics; pharmacodynamics; nlmixr; nlmixr2; rxode; rxode2; conversion; translation; NONMEM; PK; PD; PK PD; model; modeling; modelling;

    Abstract : The gold standard for pharmacometrics modeling, along with its modeling format, is currently NONMEM. In order to use other software, there is often a manual step of converting a model from one format to another, which is both time-consuming and causes manual errors. READ MORE

  3. 2. Towards individualised anaesthesia: A comparison between target-controlled infusion and closed-loop control

    University essay from Lunds universitet/Institutionen för reglerteknik

    Author : Amanda Gustafsson; [2023]
    Keywords : Technology and Engineering;

    Abstract : Individualised healthcare is the future of medicine, due to the so called inter-patient variability. The inter-patient variability involves differences in the drug response between different patients. The effect of a drug can usually be divided into pharmacokinetics (PK) and pharmacodynamics (PD). READ MORE

  4. 3. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Osama Qutishat; [2022]
    Keywords : Machine learning; pharmacometrics; Neural networks; pop-pk;

    Abstract : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. READ MORE

  5. 4. Linking Systems Models of Pharmacology with Behavioural Models of Adherence : A Feasibility Study

    University essay from KTH/Medicinteknik och hälsosystem

    Author : Simon Jenner; Dennis Amphan; [2020]
    Keywords : Pharmacology; Pharmacokinetics; Pharmacodynamics; PKPD-model; Diabetes; Adherence; Modelling; Feasibility; Farmakologi; Farmakokinetic; Farmakodynamik; PKPD-model; Diabetes; ̊Atlydnad; Modellering; Genomf ̈orbarhet;

    Abstract : Pharmacokinetic (PK)- and pharmacodynamic (PD) modeling are useful tools whenassessing treatment effect. A patient’s adherence can potentially be rate-limiting, since it isthe first process in a chain of processes that determines treatment effect. READ MORE

  6. 5. An Investigation of Semantic Interoperability with EHR systems for Precision Dosing

    University essay from KTH/Medicinteknik och hälsosystem

    Author : Jovia Namugerwa Mukwaya; [2020]
    Keywords : precision dosing; ontology; semantic interoperability; precision medicine;

    Abstract : In healthcare, vulnerable populations that are using medications with a narrow therapeutic index and wide interpatient PK/PD (pharmacokinetic/pharmacodynamic modelling) variability are increasing. As such, variable dosage regimens may result in severe therapeutic failures or adverse drug reactions (ADR). READ MORE