Essays about: "PK"

Showing result 1 - 5 of 37 essays containing the word PK.

1. 1. Translation of pharmacometric models from NONMEM to nlmixr2 and RxODE2

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Johan Borg; [2023]
   Keywords : pharmacy; pharmacokinetics; pharmacodynamics; nlmixr; nlmixr2; rxode; rxode2; conversion; translation; NONMEM; PK; PD; PK PD; model; modeling; modelling;

   Abstract : The gold standard for pharmacometrics modeling, along with its modeling format, is currently NONMEM. In order to use other software, there is often a manual step of converting a model from one format to another, which is both time-consuming and causes manual errors. READ MORE

3. 2. Towards individualised anaesthesia: A comparison between target-controlled infusion and closed-loop control

   University essay from Lunds universitet/Institutionen för reglerteknik

   Author : Amanda Gustafsson; [2023]
   Keywords : Technology and Engineering;

   Abstract : Individualised healthcare is the future of medicine, due to the so called inter-patient variability. The inter-patient variability involves differences in the drug response between different patients. The effect of a drug can usually be divided into pharmacokinetics (PK) and pharmacodynamics (PD). READ MORE

4. 3. Probing Strangeness Production in Proton-Proton Collisions with Three-Particle Correlations

   University essay from Lunds universitet/Partikel- och kärnfysik; Lunds universitet/Fysiska institutionen

   Author : Melinda Petricean; [2023]
   Keywords : Physics and Astronomy;

   Abstract : Strangeness production in small systems such as proton-proton collisions is here investigated through the use of three-particle correlations in the momentum-space coordinates η and ϕ. This method is used in order to investigate possible correlation between conservation of both strangeness and baryon number, such that the particles chosen are Λ¯pK+ and the respective charge conjugates, where Λ is a strange baryon, p¯ balances: the Balance Function and the comparative restriction of relative positions for pairs of particles within given triplets. READ MORE

5. 4. An Interactive MIDD Framework for Evaluation and Comparison of PBPK Model Performance

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Dylan Garamani; [2022]
   Keywords : MIDD; PBPK; QSP; PK; GUI;

   Abstract : Modeling and simulation are becoming indispensable elements in drug development. Mechanistic modeling is susceptible to impacting several drug development and regulatory decisions through extrapolations beyond clinically researched scenarios by using its capacity to incorporate diverse data to provide a detailed and comprehensive understanding of a physiological and biological system. READ MORE

6. 5. Study of the decay modes of Ξc0→pK−K−π+ with the LHCb experiment.

   University essay from Uppsala universitet/Kärnfysik

   Author : Yuliya Bilinskaya; [2022]
   Keywords : Particle physics; hadron physics; resonance; particle decay; LHCb; Dalitz plot; Lambda resonance; Delta resonance;

   Abstract : This thesis reports the first indications of the Λ(1520) and ∆(1232)++ decay modes in the Ξc0 → pK−K−π+ decay. The obtained fractions relative the inclusive Ξc0 → pK−K−π+ decay are (6.4±0.6)% and (32. READ MORE