Essays about: "Pharmacodynamics"

Showing result 1 - 5 of 13 essays containing the word Pharmacodynamics.

  1. 1. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    University essay from Uppsala universitet/Analytisk kemi

    Author : Maryam Dost; [2024]
    Keywords : Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Abstract : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. READ MORE

  3. 2. Translation of pharmacometric models from NONMEM to nlmixr2 and RxODE2

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Johan Borg; [2023]
    Keywords : pharmacy; pharmacokinetics; pharmacodynamics; nlmixr; nlmixr2; rxode; rxode2; conversion; translation; NONMEM; PK; PD; PK PD; model; modeling; modelling;

    Abstract : The gold standard for pharmacometrics modeling, along with its modeling format, is currently NONMEM. In order to use other software, there is often a manual step of converting a model from one format to another, which is both time-consuming and causes manual errors. READ MORE

  4. 3. Towards individualised anaesthesia: A comparison between target-controlled infusion and closed-loop control

    University essay from Lunds universitet/Institutionen för reglerteknik

    Author : Amanda Gustafsson; [2023]
    Keywords : Technology and Engineering;

    Abstract : Individualised healthcare is the future of medicine, due to the so called inter-patient variability. The inter-patient variability involves differences in the drug response between different patients. The effect of a drug can usually be divided into pharmacokinetics (PK) and pharmacodynamics (PD). READ MORE

  5. 4. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Osama Qutishat; [2022]
    Keywords : Machine learning; pharmacometrics; Neural networks; pop-pk;

    Abstract : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. READ MORE

  6. 5. Identifiability of pharmacological models from data

    University essay from Lunds universitet/Institutionen för reglerteknik

    Author : Amina Gojak; [2021]
    Keywords : Technology and Engineering;

    Abstract : In order to automate anaesthesia in patients using propofol, closed-loop control systems with models that describe the time course of the drug effects on the body are required, usually being represented by pharmacokinetics and pharmacodynamics(PKPD). This thesis focused on evaluating parameter identifiability for the PK part of the model, using a model proposed by Eleveld et al. READ MORE