Essays about: "Population PK modeling"

Found 2 essays containing the words Population PK modeling.

1. 1. Evaluation of Robust Model Building Tools to Improve the Efficiency of Non-linear Mixed Effect Model Building Workflows

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Karin Norgren; [2021]
   Keywords : Population PK modeling; Pharmacometrics; NLME modeling;

   Abstract : Population PK models aim to describe the change in drug concentration over time for a specific population. The populations in population PK modelling often refer to subjects in a clinical trial of a potential drug candidate. READ MORE

3. 2. Individualization of fixed-dose combination regimens : Methodology and application to pediatric tuberculosis

   University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Author : Gunnar Yngman; [2015]
   Keywords : pharmacometrics; pharmacokinetics; PK; population pharmacokinetics; optimal design; FDC; fixed-dose combination; pediatrics; tuberculosis; rifampicin; pyrazinamide; isoniazid; ethambutol; modeling; simulation; estimation; allometric scaling; stochastical simulation and estimation; NONMEM; MATLAB; FO; FOCE; Expectation-Maximization algorithm; importance sampling; Nelder-Mead method; logistic function; discontinuity; euclidean distance; Sammon mapping; global minimum; local minima;

   Abstract : Introduction: No Fixed-Dose Combination (FDC) formulations currently exist for pediatric tuberculosis (TB) treatment. Earlier work implemented, in the software NONMEM, a rational method for optimizing design and individualization of pediatric anti-TB FDC formulations based on patient body weight, but issues with parameter estimation, dosage strata heterogeneity and representative pharmacokinetics remained. READ MORE