Essays about: "Proteasome inhibitor"

Found 3 essays containing the words Proteasome inhibitor.

1. 1. Metabolic Modelling of Differential Drug Response to Proteasome Inhibitors in Glioblastoma Multiforme

   University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Author : Clara Bernedal Nordström; [2021]
   Keywords : ;

   Abstract : This project was built upon a previous study (Johansson et al.2020) that tested multiple drugs on glioblastoma cell lines and found a big division between the drug response for proteasome inhibitors. READ MORE

3. 2. Inhibitory effect on the proteasome regulatory subunit, RPN11/POH1, with the use of Capzimin-PROTAC to trigger apoptosis in cancer cells

   University essay from Linköpings universitet/Kemi

   Author : Andreas Holmqvist; [2020]
   Keywords : Proteolysis targeting chimera PROTAC ; Cancer therapeutics; Ubiquitin proteasome system UPS ; Cancer; Chemotherapy; Proteasome inhibitor; Capzimin;

   Abstract : Most patients diagnosed with cancer will receive systematic chemotherapy at some point during their illness, which almost always cause severe side effects for the patients such as, anemia, nausea and vomiting. The problems with today’s chemotherapy is not only that it cause severe side effects, but also that the cancer may develop resistance to the therapy, which is why the development of a new type of therapeutic agent is in dire need. READ MORE

4. 3. Genetic analysis of the fission yeast

   University essay from Lunds universitet/Examensarbeten i molekylärbiologi

   Author : Nima Borhan Fakouri; [2012]
   Keywords : Biology and Life Sciences;

   Abstract : ABSTRACT Ribonucleotide reductase (RNR) catalyzes the rate‐limiting step of dNTP production. The availability of finely tuned dNTP pools is very important to maintain genome stability during DNA synthesis for replication and repair. Therefore the activity of RNR is tightly regulated via various mechanisms. READ MORE