Essays about: "Protein aggregering"

Showing result 1 - 5 of 9 essays containing the words Protein aggregering.

  1. 1. Effect of DNAJB6 on α-synuclein amyloid fibril aggregation and dis-aggregation

    University essay from Lunds universitet/Biofysikalisk kemi

    Author : Josef Getachew; [2023]
    Keywords : α-synuclein; alpha-synuclein; chaperones; DNAJB6; the unhappy chaperone; parkinsons disease; biophysical chemistry; biochemistry; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Abstract : Amyloid proteins are a group of proteins with the ability to form large fibrillar aggregates, identifiable by their cross-β core structure. These aggregates are linked to several different neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease and due to the growing rate of people diagnosed, there is a need to combat these diseases. READ MORE

  3. 2. Aggregation mechanisms of proteins in liquid formulations

    University essay from KTH/Kemi

    Author : Amanda Hamrin; [2022]
    Keywords : Protein aggregering; seedingmekanism; dynamic light scattering; differential scanning calorimetry; Somatropin; monoklonal antikropp; Protein aggregation; seeding mechanism; dynamic light scattering; differential scanning calorimetry; somatropin; monoclonal antibody;

    Abstract : Biologiska läkemedel har under det senaste århundradet utökats, och under de senaste 25 åren så har proportionen av godkända biologiska läkemedel har ökat för behandlingen av sjukdomar, vaccin, och diagnostik. Det finns flera olika mekanismer för protein aggregering, och en av dessa är seeding, vilket innebär aggregering inducerat av tillsatta aggregat eller förekomsten av strukturförändringar i proteinet. READ MORE

  4. 3. Towards Ca2+ Responsive Reticular Materials. An Evaluation of Suitable Conditions for Self-Assembly of the Protein S100G

    University essay from Lunds universitet/Biofysikalisk kemi

    Author : Andreas Carlsson; [2021]
    Keywords : protein material; domain swapping; EF-hand; calbindin D9k; Ca2 dependent; aggregation; S100G; protein design; biophysical chemistry; Biology and Life Sciences;

    Abstract : Att bygga material av proteiner är en konst som våra kroppar är specialister på. Men när vi medvetet försöker designa proteinmaterial, så blir det tydligt hur komplexa och svårstyrda biofysikens lagar är. READ MORE

  5. 4. Korrelation av kliniska och genetiska data hos älgar diagnosticerade med och utan Moose Wasting Syndrome

    University essay from SLU/Dept. of Animal Breeding and Genetics

    Author : Rosie Johannesson; [2020]
    Keywords : älg; Moose Wasting Syndrome; undernäring; sjukdomsdata;

    Abstract : År 1985 upptäcktes en sjukdom som drabbade svenska älgar. Sjukdomen fick namnet Moose Wasting Syndrome (MWS). Älgarna som hittades var i mycket dålig kondition eller självdöda. Symptomen på MWS är anorexi, svaghet, nedsatt syn, minskad skygghet, utmärgling och diarré. READ MORE

  6. 5. The anti-amyloidogenic chaperone DNAJB6 and its interaction with other chaperones

    University essay from Lunds universitet/Matematisk statistik; Lunds universitet/Kemiska institutionen

    Author : Gemma Nilsson; [2020]
    Keywords : chaperones; DNAJB6; Hsc70; Hsp110; ATP-hydrolysis; Ab42; polyQ; biochemistry; biokemi; Chemistry;

    Abstract : In order to maintain proteins’ functionality their native folding state must be preserved. Chaperones fold other proteins and DNAJ-chaperones may collaborate with Hsc70 chaperones to prevent aggregation of aggregation-prone peptides such as polyQ and Aβ42, which form fibrils in currently incurable diseases as Huntington’s and Alzheimer’s, respectively. READ MORE