Essays about: "Protein crystallography"
Showing result 1 - 5 of 20 essays containing the words Protein crystallography.
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1. Acoustic Focusing of Lysozyme Crystals
University essay from KTH/Tillämpad fysikAbstract : Acoustic focusing of microscale protein crystals with acoustophoresis technology could reduce clogs during experiments with the scientific technique serial femtosecond x-ray crystallography (SFX). SFX determines molecular structures of proteins, these structures are valuable in drug discovery and fundamental biomedical research. READ MORE
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2. Expression and purification of pyruvate transporting human mitochondrial pyruvate carrier (MPC) protein complex for structural studies
University essay from Lunds universitet/Examensarbeten i molekylärbiologiAbstract : Pyruvate is one of the main molecules needed for the citric acid cycle, which produces energy in the form of ATP. The citric acid cycle reaction occurs in the mitochondrial matrix, and for pyruvate to participate in the reaction, it needs to be transported from the cytosol across the mitochondrial membranes into the mitochondrial matrix. READ MORE
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3. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus
University essay from Lunds universitet/Tillämpad biokemi; Lunds universitet/BeräkningskemiAbstract : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. READ MORE
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4. Investigation of the function of the SH3-like domain of the Saccharopolyspora erythraea iron-dependent regulator
University essay from Uppsala universitet/Institutionen för kemi - BMCAbstract : The bacterium Saccharopolyspora erythraea is utilized to produce the widely used antibiotic erythromycin. With the increasing problem of antibiotic resistance, the development of derivatives of the drug is of great importance. To produce antibiotics biosynthetically, it is crucial to understand the metabolic pathways utilized by the bacterium. READ MORE
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5. Fragment-screening by X-ray crystallography of human vaccinia related kinase 1
University essay from Linköpings universitet/Institutionen för fysik, kemi och biologiAbstract : Fragment-screening by X-ray crystallography (XFS) is an expensive and low throughput fragment drug discovery screening method, and it requires a lot of optimization for each protein target. The advantages with this screening method are that it is very sensitive, it directly gives the three-dimensional structure of the protein-fragment complexes, and false positives are rarely obtained. READ MORE
