Essays about: "Protein misfolding"
Found 5 essays containing the words Protein misfolding.
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1. Effect of DNAJB6 on α-synuclein amyloid fibril aggregation and dis-aggregation
University essay from Lunds universitet/Biofysikalisk kemiAbstract : Amyloid proteins are a group of proteins with the ability to form large fibrillar aggregates, identifiable by their cross-β core structure. These aggregates are linked to several different neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease and due to the growing rate of people diagnosed, there is a need to combat these diseases. READ MORE
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2. Competition between Phase Separation and Micellization in a Coarse-Grained Protein Model with Two Components
University essay from Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisationAbstract : Intrinsically disordered proteins (IDPs) are widely believed to play a key role in the for- mation of intracellular biomolecular condensates through liquid-liquid phase separation (LLPS). Furthermore, it has been shown in vitro that several IDPs are able to phase sepa- rate on their own. READ MORE
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3. Development of an antibioticsresistancebased method fordirected evolution of proteases
University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)Abstract : Proteases have a fundamental role in regulating diverse biological processes and are important in the biotechnological and medical fields. Therapeutic proteases have great potential but have been limited due to the lack of high throughput protein engineering methods. READ MORE
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4. Synthesis of proteophenes that can be utilized as fluorescent ligands for biological targets
University essay from Linköpings universitet/KemiAbstract : Small fluorescent probes are important tools when studying protein aggregates involved in different neurodegenerative diseases, such as Alzheimer’s disease. Luminescent conjugated oligothiophenes have been developed and shown to be excellent ligands when studying morphology among amyloids, due to their conjugated thiophene backbone that provides them with unique photophysical properties. READ MORE
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5. Study of co-translational folding of E. coli dihydrofolate reductase using fluorescence resonance energy transfer (FRET)
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : In prokaryotes, protein synthesis and folding are often coupled, and the protein begins to fold from the N-terminus as it is being synthesized. It has been hypothesised that there could be kinetic coupling of the speed of translation and the folding, which means that an altered rate of synthesis can cause a possible misfolding of the protein. READ MORE
