Essays about: "Protein structure determination"

Showing result 1 - 5 of 19 essays containing the words Protein structure determination.

  1. 1. Determination of Proton Beam Waist Positions Using Beam Position Monitors

    University essay from Lunds universitet/Fysiska institutionen; Lunds universitet/European Spallation Source ESS AB; Lunds universitet/Synkrotronljusfysik

    Author : Gustav Gird Fahlström; [2022]
    Keywords : ESS; European Spallation Source; Proton beam; waist; BPM; Method; transverse; beam dynamics; beam physics; Lattice Error; Matrix formalism; Python; trajectory simulation; physics; Physics and Astronomy;

    Abstract : In this work, we examine a novel method for the determination of proton beam waist locations using beam position monitors. Based on the lattice of the final transport line section of the European Spallation Source linac, a simplified version of the beam line composed of quadrupole magnets and correctors is constructed in Python using a matrix formalism. READ MORE

  3. 2. Engineered imaging scaffolds for cryo-EM of small proteins of interest

    University essay from KTH/Proteinvetenskap

    Author : Oscar Friberg; [2022]
    Keywords : Protein structure determination; single-particle cryo-EM; imaging scaffold; size limitation problem; affibody; YgjG.;

    Abstract : Strukturbestämning av proteiner är viktigt för att kunna förstå deras funktion och en snabbt utvecklande metod inom fältet är kryoelektronmikroskopi. Storleksbegränsningar förhindrar en bredare applikation av metoden eftersom små proteiner har för låg signal i förhållande till bakgrund för att kunna visualiseras som enstaka partiklar i elektronmiksoskopibilder. READ MORE

  4. 3. Crystallization, optimization, and crystal structure determination of ligands in complex with galectin-8N

    University essay from Lunds universitet/Kemiska institutionen

    Author : George Larsson; [2022]
    Keywords : Biochemistry; Structural Biochemistry; Galectin-8; Protein Crystallization; Chemistry;

    Abstract : This thesis focuses on the protein “galectin-8N” which is a lectin protein that takes part in several physiological functions such as inflammation, autophagy, cell migration, and more. The project has three objectives: to observe and increase the reproducibility of crystallization of two variants (wildtype and mutant) of the human protein galectin-8N and to analyze the binding site when three different novel ligands are each inserted. READ MORE

  5. 4. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus

    University essay from Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Author : Elin Öberg; [2022]
    Keywords : x-ray crystallography; protein crystallization; Venezuelan equine encephalitis virus; structure-based drug design; applied biochemistry; Technology and Engineering;

    Abstract : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. READ MORE

  6. 5. The effect of water on the orientation of a protein in an electric field

    University essay from Uppsala universitet/Institutionen för fysik och astronomi

    Author : Gideon Elfrink; [2022]
    Keywords : Structure determination; Gromacs; tutorial; Molecular Dynamics; protein; ubiquitin;

    Abstract : Structure determination of proteins is vital for the understanding of their function. It often relies on techniques that use intense X-ray pulses to create diffraction patterns of protein crystals, which then contain information on the three-dimensional structure of the crystallised protein. READ MORE