Essays about: "Protein-protein interaction"

Showing result 1 - 5 of 23 essays containing the words Protein-protein interaction.

  1. 1. Gene Biomarker Identification by Distinguishing Between Small-Cell and Non-Small Cell Lung Cancer Through a Module-Based Approach

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Noor Haval Jamal; [2023]
    Keywords : ;

    Abstract : Lung cancer is the leading cause of cancer-related deaths worldwide and is divided into two broad histological types, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Network module-based approach is applied to lung cancer subtypes in order to analyze and compare the results with previous literature and thus discover new genetic biomarkers and/or confirm previously discovered ones. READ MORE

  3. 2. The Effect of Interactive Selection on Personalized Drug Prediction Using Interactomes : Examination of Parameters Impacting Drug Treatment Rankings from Network Models for Covid-19 Patients

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Cornelia Torell; [2023]
    Keywords : Precision Medicine; Pharmacogenomics; Biomarkers; Covid-19; Digital Twins; Network Modeling; Interactomes; Protein-Protein Interaction Networks; Differentially Expressed Genes; Principal Coordinate Analysis; Precisionsmedicin; Farmakogenetik; Biomarkörer; Covid-19; Digitala tvillingar; Nätverksmodellering; Interaktom; Proteininteraktionsnätverk; Sjukdomsrelaterade gener; Principalkoordinatanalys;

    Abstract : Patients not responding to therapy as expected is one of the most pressing healthcare concerns of today. It causes economical, medical and societal issues along with suffering for patients. This project aimed to address this problem and evaluate how to find the best suited drug treatments for individual patients to treat Covid-19. READ MORE

  4. 3. Capturing genes with high impact based on reconstruction errors produced by variational autoencoders

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Utz Lovis Rieger; [2023]
    Keywords : ;

    Abstract : In this work we present a novel method to extract potential hub genes, transcription factors and regions with densely interconnected protein-protein-interaction networks from RNAseq data. To achieve this we deploy variational autoencoders, a generative machine learning framework, and extract the gene-wise reconstruction errors. READ MORE

  5. 4. Comprehensive Analysis of lncRNA and circRNA Mediated ceRNA network in Psoriasis

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Saima Imran; [2022]
    Keywords : ;

    Abstract : Evidence is accumulating that noncoding RNAs and circRNA are involved in psoriasis; however, the competing endogenous RNA (ceRNA) mediated regulatory mechanisms in psoriasis are rarely reported. The research study aimed to comprehensively investigate the differences in the expression levels of circular RNA (circRNA), long non-coding RNA (lncRNA), microRNA (miRNA/miR), and mRNA in psoriasis. READ MORE

  6. 5. Characterization of biological role of FKBP51-HSP90 protein-protein interactions in novel knock-in mouse model

    University essay from KTH/Proteinvetenskap

    Author : Shaoxun Xie; [2022]
    Keywords : FK506-binding protein 51kDa; heat shock protein 90kDa; glucocorticoid signaling pathway; dexamethasone; knock-in mouse model; FK506-bindande protein 51kDa; värmechockprotein 90kDa; glucocorticoiders signalvägar; dexamethasone; knock-in musmodell;

    Abstract : Värmechockprotein 90 kDa (HSP90) bildar ett anmärkningsvärt komplicerat nätverk med en mängd olika cochaperones. Komplexet av FK506-bindande protein 51 kDa (FKBP51) och HSP90 förmedlar proteinveckning och funktion, främjar tau aggregation vid Alzheimers sjukdom och påverkar stressrelaterade störningar, fetma, typ två-diabetes, etc. READ MORE