Essays about: "SPPS"

Showing result 1 - 5 of 13 essays containing the word SPPS.

1. 1. Greening peptide chemistry by using NBP as solvent for SPPS

   University essay from Lunds universitet/Centrum för analys och syntes

   Author : Andrea Ölander; [2022]
   Keywords : SPPS; Green chemistry; Peptide Synthesis; Organic chemistry; Organisk kemi; Chemistry;

   Abstract : The preferred method for synthesising therapeutic peptides today is by Solid-Phase Peptide Synthesis (SPPS). SPPS is a wasteful process, where the main component of the waste is hazardous solvents, i.e., N,N-dimethylformamide (DMF), N-methylpyrrolidone (NMP) or dichloromethane (DCM). READ MORE

3. 2. Streamlining the manufacturing of biotherapeutics : SPPS vs. Recombinant protein production

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Matilda Carlson; Alma Hansen; Tyra Levin; Moa Rick; Frida Tallqvist; Malin Tiefensee; [2021]
   Keywords : ;

   Abstract : In this paper we have researched two methods for peptide synthesis; solid phase peptide synthesis (SPPS) and recombinant protein production, hereafter called recombinant production. The goal was to create a decision support that can be of use when choosing a production method for a given peptide. READ MORE

4. 3. Production and Evaluation of a Bombesin Analogue Conjugated to the Albumin-Binding Domain and DOTA for Prostate Cancer Radiotherapy

   University essay from KTH/Proteinvetenskap

   Author : Fredrika Landmark; [2021]
   Keywords : bombesin; prostate cancer; radiotherapy; human serum albumin; half-life extension; bombesin; prostatacancer; radioterapi; humant serumalbumin; halveringstidsförlängning;

   Abstract : Prostate cancer is one of the most common types of cancer worldwide and claims hundreds of thousands of lives annually. Currently the most common treatment for prostate cancer is external beam radiotherapy, however, this treatment comes with serious side effects since it lacks selectivity for the cancer cells. READ MORE

5. 4. Minimizing Liquid Waste in Peptide Synthesis : A New Application for the Rotating Bed Reactor

   University essay from Umeå universitet/Institutionen för fysik

   Author : Peter Nordström; [2021]
   Keywords : Chemical reactor; Rotating Bed Reactor; Solid-phase peptide synthesis; Peptide synthesis.;

   Abstract : Peptide drugs are used to treat a broad spectrum of diseases such as cancer and HIV and have many more promising applications, such as new vaccines against SARS-CoV-2. The most popular manufacturing method for peptides is solid-phase peptide synthesis (SPPS). The main drawback of SPPS is that it is a costly and wasteful process. READ MORE

6. 5. The synthesis and analysis of a bombesin analogue for radiotherapy of prostate cancer

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Ábel Nagy; [2019]
   Keywords : Prostate cancer; radionuclide therapy; bombesin; gastrin-releasing peptide receptor; albumin binding domain; SPPS; RM26 analogue;

   Abstract : Targeted radionuclide therapy is becoming a widely used cancer treatment strategy. By radiolabeling receptor-specific peptides, cancer cells overexpressing the receptor can be selectively targeted, and the cytotoxic radionuclide can be delivered to the target cell or tissue for therapeutic or diagnostic purposes. READ MORE