Essays about: "Smad2"

Found 4 essays containing the word Smad2.

  1. 1. TGFβ2 may phosphorylate SMAD2, SMAD3, ERK1/2, JNK and p38 in human umbilical vein endothelial cells

    University essay from Örebro universitet/Institutionen för hälsovetenskaper

    Author : Shafir Sabbag; [2023]
    Keywords : ;

    Abstract : Introduction The dysfunction of human endothelial cells caused by exposure to inflammatory mediators, such as TGFβ, leads to development of diseases, such as atherosclerotic diseases. TGFβ mediated endothelial dysfunction may involve MMP-9. MMP9 is highly expressed in atherosclerotic plaques. READ MORE

  3. 2. 1,25(OH)2D3 and Initial Regulation of Smad2/3 Activity in PC-3 Prostate Cancer Cells

    University essay from Institutionen för vård och natur

    Author : Anette Stahel; [2009]
    Keywords : prostate cancer; PC-3; vitamin D; 1; 25 OH 2D3; TGFβ; Smad2; Smad3;

    Abstract : The vitamin D metabolite 1,25(OH)2D3 has long been known to inhibit growth of prostate cancer cells and this mainly through a VDR-mediated pathway controlling target gene expression, resulting in cell cycle arrest, apoptosis and differentiation. Another major way in which 1,25(OH)2D3 inhibits cell growth in prostate cancer is via membrane-initiated steroid signalling, which triggers activation of signal cascades upon steroid binding to a receptor complex, leading to induction of genes regulating cell growth, proliferation and apoptosis. READ MORE

  4. 3. Effects of 1,25(OH)2D3 on Smad2 Activity in PC-3 Prostate Cancer Cells

    University essay from Institutionen för vård och natur

    Author : Anette Stahel; [2009]
    Keywords : prostate cancer; PC-3; vitamin D; 1; 25 OH 2D3; TGFβ; Smad2; Smad3;

    Abstract : The vitamin D metabolite 1,25(OH)2D3 has long been known to inhibit growth of prostate cancer cells and this mainly through a VDR-mediated pathway controlling target gene expression, resulting in cell cycle arrest, apoptosis and differentiation. Another major way inwhich 1,25(OH)2D3 inhibits cell growth in prostate cancer is via membrane-initiated steroid signalling, which triggers activation of signal cascades upon steroid binding to a receptor complex, leading to induction of genes regulating cell growth, proliferation and apoptosis. READ MORE

  5. 4. 1,25(OH)2D3 Initially Reduces TGFβ Activity in PC-3 Prostate Cancer Cells

    University essay from Institutionen för vård och natur

    Author : Anette Stahel; [2008]
    Keywords : prostate cancer; PC-3; proliferation; growth inhibition; vitamin D; 1; 25 OH 2D3; TGFβ; Smad2; Smad3;

    Abstract : The vitamin D metabolite 1,25(OH)2D3 has long been known to inhibit growth of prostate cancer cells and this mainly through a VDR-mediated pathway controlling target gene expression, resulting in cell cycle arrest, apoptosis and differentiation. Another major way in which 1,25(OH)2D3 inhibits cell growth in prostate cancer is via membrane-initiated steroid signalling, which triggers activation of signal cascades upon steroid binding to a receptor complex, leading to induction of genes regulating cell growth, proliferation and apoptosis. READ MORE