Essays about: "Stepwise Expectation Maximization"

Found 2 essays containing the words Stepwise Expectation Maximization.

1. 1. Improving the speed and quality of an Adverse Event cluster analysis with Stepwise Expectation Maximization and Community Detection

   University essay from Uppsala universitet/Institutionen för medicinska vetenskaper

   Author : Nils Erlanson; [2020]
   Keywords : Adverse Drug Reactions; Pharmacovigilance; Cluster Analysis; Stepwise Expectation Maximization; Community Detection; Topic Modelling;

   Abstract : Adverse drug reactions are unwanted effects alongside the intended benefit of a drug and might be responsible for 3-7\% of hospitalizations. Finding such reactions is partly done by analysing individual case safety reports (ICSR) of adverse events. The reports consist of categorical terms that describe the event. READ MORE

3. 2. Individualization of fixed-dose combination regimens : Methodology and application to pediatric tuberculosis

   University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Author : Gunnar Yngman; [2015]
   Keywords : pharmacometrics; pharmacokinetics; PK; population pharmacokinetics; optimal design; FDC; fixed-dose combination; pediatrics; tuberculosis; rifampicin; pyrazinamide; isoniazid; ethambutol; modeling; simulation; estimation; allometric scaling; stochastical simulation and estimation; NONMEM; MATLAB; FO; FOCE; Expectation-Maximization algorithm; importance sampling; Nelder-Mead method; logistic function; discontinuity; euclidean distance; Sammon mapping; global minimum; local minima;

   Abstract : Introduction: No Fixed-Dose Combination (FDC) formulations currently exist for pediatric tuberculosis (TB) treatment. Earlier work implemented, in the software NONMEM, a rational method for optimizing design and individualization of pediatric anti-TB FDC formulations based on patient body weight, but issues with parameter estimation, dosage strata heterogeneity and representative pharmacokinetics remained. READ MORE