Essays about: "Structural bioinformatics"

Showing result 1 - 5 of 11 essays containing the words Structural bioinformatics.

  1. 1. Whole-Genome Sequencing of two Swedish Individuals on PromethION

    University essay from Lunds universitet/Examensarbeten i bioinformatik

    Author : Nazeefa Fatima; [2019]
    Keywords : Biology and Life Sciences;

    Abstract : Background: Chromosomes can undergo various changes such as deletions, inversions, insertions, and/or translocations resulting in structural variation differences between individuals. Structural variants are a common source of variability in the human genome and have been known to be associated with common diseases such as autism, cancer, and rare human diseases [1, 2]. READ MORE

  2. 2. Modifying a Protein-Protein Interaction Identifier with a Topology and Sequence-Order Independent Structural Comparison Method

    University essay from Linköpings universitet/Bioinformatik

    Author : Joakim Johansson; [2018]
    Keywords : PPI; Protein-protein interaction; Machine learning; Protein modelling; Structural bioinformatics; Structural alignment; Sequence-order independent;

    Abstract : Using computational methods to identify protein-protein interactions (PPIs) supports experimental techniques by using less time and less resources. Identifying PPIs can be made through a template-based approach that describes how unstudied proteins interact by aligning a common structural template that exists in both interacting proteins. READ MORE

  3. 3. Identifying Pathogenic Amino Acid Substitutions in Human Proteins Using Deep Learning

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Alexander Kvist; [2018]
    Keywords : Bioinformatics; deep learning; proteomics; mutations; single nucleotide polymorphism; SNP; convolutional neural network; variant effect prediction;

    Abstract : Many diseases of genetic origin originate from non-synonymous single nucleotide polymorphisms (nsSNPs). These cause changes in the final protein product encoded by a gene. Through large scale sequencing and population studies, there is growing availability of information of which variations are tolerated and which are not. READ MORE

  4. 4. SVenX: A highly parallelized pipeline for structural variation detection using linked read whole genome sequencing data

    University essay from Lunds universitet/Examensarbeten i bioinformatik

    Author : Vanja Börjesson; [2018]
    Keywords : Biology and Life Sciences;

    Abstract : Genomic rearrangements larger than 50 bp are called structural variants. As a group, they affect the phenotypic diversity among humans and have been associated with many human disorders including neurodevelopmental disorder and cancer. READ MORE

  5. 5. PePIP : a Pipeline for Peptide-Protein Interaction-site Prediction

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Isak Johansson-Åkhe; [2017]
    Keywords : PPI; Protein-protein interaction; Protein-peptide interaction; Random forest; Bioinformatics; Binding-site prediction; Structural Alignment;

    Abstract : Protein-peptide interactions play a major role in several biological processes, such as cellproliferation and cancer cell life-cycles. Accurate computational methods for predictingprotein-protein interactions exist, but few of these method can be extended to predictinginteractions between a protein and a particularly small or intrinsically disordered peptide. READ MORE