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Showing result 1 - 5 of 18 essays matching the above criteria.
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1. Detecting structural variants in the DNA of the inbred Scandinavian wolf
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Only 40 years ago, just three individuals made the journey from Finland/Russia to found the current wolf population in the southwest of Sweden. This population, that to this date descends from less than 10 founders, has a substantial increased extinction risk due to inbreeding. READ MORE
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2. Predicting and classifying atrial fibrillation from ECG recordings using machine learning
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Atrial fibrillation is one of the most common types of heart arrhythmias, which can cause irregular, weak and fast atrial contractions up to 600 beats per minute. Atrial fibrillation has increased prevalence with age and is associated with increased risks of ischemia, as blood clots can form due to the weak contractions. READ MORE
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3. Identifying structural variants from plant short-read sequencing data
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : .... READ MORE
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4. Identification of novel loss of heterozygosity collateral lethality genes for potential applications in cancer
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Over the course of this project, I demonstrate the utility of a 4-phase analysis pipeline in the context of cancer therapy and the associated search for antineoplastic drug candidates. I showcase a repeatable means for generating lists of potential targets which may be used in conjunction with methods like small molecule screening as part of a search for broadly effective antineoplastic agents. READ MORE
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5. Class switching mechanism in antibodies : A conformational and structural investigation of the B-cell repertoire diversity of the CDR3
University essay from Högskolan i Skövde/Institutionen för hälsovetenskaperAbstract : A process called class switching recombination (CSR) regulates the production of isotypes by enabling the switch of producing unspecific IgM or IgD to producing IgG, IgE, or IgA by causing an irreversible genomic rearrangement. Recent studies indicate a gap in the identification of the molecular mechanisms underlying CSR. READ MORE