Essays about: "Structural bioinformatics"

Showing result 11 - 15 of 18 essays containing the words Structural bioinformatics.

  1. 11. SVenX: A highly parallelized pipeline for structural variation detection using linked read whole genome sequencing data

    University essay from Lunds universitet/Examensarbeten i bioinformatik

    Author : Vanja Börjesson; [2018]
    Keywords : Biology and Life Sciences;

    Abstract : Genomic rearrangements larger than 50 bp are called structural variants. As a group, they affect the phenotypic diversity among humans and have been associated with many human disorders including neurodevelopmental disorder and cancer. READ MORE

  3. 12. PePIP : a Pipeline for Peptide-Protein Interaction-site Prediction

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Isak Johansson-Åkhe; [2017]
    Keywords : PPI; Protein-protein interaction; Protein-peptide interaction; Random forest; Bioinformatics; Binding-site prediction; Structural Alignment;

    Abstract : Protein-peptide interactions play a major role in several biological processes, such as cellproliferation and cancer cell life-cycles. Accurate computational methods for predictingprotein-protein interactions exist, but few of these method can be extended to predictinginteractions between a protein and a particularly small or intrinsically disordered peptide. READ MORE

  4. 13. Searching for novel protein-protein specificities using a combined approach of sequence co-evolution and local structural equilibration

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Olle Nordesjö; [2016]
    Keywords : Biotechnology; Bioinformatics; Molecular Structure; Protein Conformation; Computing Methodologies; Protein-protein interaction; Binding affinity; Mutation analysis; Amino acid mutation; in-silico binding affinity prediction; Two-component regulatory system; Histidine Kinase; Response Regulator; Prediction; PhoQ; PhoP; Phosphatase;

    Abstract : Greater understanding of how we can use protein simulations and statistical characteristics of biomolecular interfaces as proxies for biological function will make manifest major advances in protein engineering. Here we show how to use calculated change in binding affinity and coevolutionary scores to predict the functional effect of mutations in the interface between a Histidine Kinase and a Response Regulator. READ MORE

  5. 14. Protein-Protein Docking Using Starting Points Based On Structural Homology

    University essay from Linköpings universitet/Bioinformatik

    Author : Martin Hyvönen; [2015]
    Keywords : In silico; Rosetta Dock; Bound docking; PPI; Bioinformatics; InterPred;

    Abstract : Protein-protein interactions build large networks which are essential in understanding complex diseases. Due to limitations of experimental methodology there are problems with large amounts of false negative and positive interactions; and a large gap in the amount of known interactions and structurally determined interactions. READ MORE

  6. 15. Bioinformatics analysis of whole genome resequencing data in the chicken

    University essay from SLU/Dept. of Animal Breeding and Genetics

    Author : Khurram Maqbool; [2010]
    Keywords : Next generation sequencing; structural variation; insertion; deletion; chicken;

    Abstract : One of the most important challenges in human medicine is the identification of genetic variants underlying complex diseases but we are still not able to assess the risk of disease by genetic profiling. Also, as the complete functional properties remain unknown for most genes it is very important to further functionally annotate genomes. READ MORE