Essays about: "Structural biology"

Showing result 1 - 5 of 51 essays containing the words Structural biology.

  1. 1. A Machine Learning Approach on Analysis of Emission Spectra for Application in XFEL Experiments

    University essay from Uppsala universitet/Institutionen för fysik och astronomi

    Author : Harald Agelii; [2023]
    Keywords : Structural biology; Machine learning; Neural networks; emission spectrum; XFEL; X-ray free electron laser; SFX; Serial femtosecond X-ray crystallography; Proteins; Diagnostics;

    Abstract : In this thesis we investigate two potential applications of machine learning in the context of X-ray imaging and spectroscopy of biological samples, particularly such using X-ray free electron lasers (XFEL). We first investigate the possibility of using an emission spectrum, recorded from a sample after being probed by an incident X-ray, as a diagnostic tool. READ MORE

  3. 2. Characterization of Mitilysin Pores by Cryo-electron Microscopy

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Vladimir Novakovic; [2023]
    Keywords : Mitilysin; Mly; Structural Biology; Cryo-EM; pore; toxin; pore forming proteins; pore forming toxins; PFP; PFT;

    Abstract : Pore forming toxins (PFTs) are a large group of proteins found mainly in bacteria with some exceptions found in animals. They bind and form pores in their target membranes and form pores, which leads to cell death. Among these are cholesterol-dependent cytolysins (CDC), which require the presence of cholesterol to bind target membranes. READ MORE

  4. 3. Determining Protein Conformational Ensembles by Combining Machine Learning and SAXS

    University essay from KTH/Tillämpad fysik

    Author : Samuel Eriksson Lidbrink; [2023]
    Keywords : AlphaFold; AlphaFold2; SAXS; protein conformational ensembles; machine learning; protein conformations; reweighting; SAXS; AlphaFold; AlphaFold2; proteinkonformationsensembler; maskininlärning; proteinkonformationer; omviktning;

    Abstract : In structural biology, immense effort has been put into discovering functionally relevant atomic resolution protein structures. Still, most experimental, computational and machine learning-based methods alone struggle to capture all the functionally relevant states of many proteins without very involved and system-specific techniques. READ MORE

  5. 4. Towards time-resolved cryo-EM of SARS-CoV-2 replication-transcription complex and Staphylococcus aureus DNA gyrase

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Anna Králová; [2023]
    Keywords : time-resolved cryo-EM; DNA gyrase; SARS-CoV-2; replication-transcription complex; protein purification;

    Abstract : Time-resolved cryo-EM has already provided ground-breaking discoveries in various fields, including structural biology, biochemistry, and drug development. Compared to traditional structural biology methods where mostly stabilized conformations are reconstructed, the main advantage of time-resolved cryo-EM is its ability to capture dynamic processes in biological samples at near-atomic resolution, which allows for studying biological structures as they change and interact in real-time. READ MORE

  6. 5. Approaches to Structural Characterization of a Heteromeric GABA(A)R

    University essay from KTH/Tillämpad fysik

    Author : Alexander Stevens; [2023]
    Keywords : Applied Physics; Biophysics; Molecular Biophysics; GABA A R; LGIC; pLGIC; Tillämpad Fysik; Biofysik; Molekylär Biofysik; GABA A R; LGIC; pLGIC;

    Abstract : Structural biology has become an important part of researching various diseases and drug development. In this thesis, I provide details on how I worked with approaches to structural characterization of a heteromeric GABA(A)R. READ MORE