Essays about: "Transferrin"

Found 5 essays containing the word Transferrin.

1. 1. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Jonathan Efverström; [2023]
   Keywords : Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

   Abstract : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. READ MORE

3. 2. Identification of Trypsin Digested Transferrin using HPLC and MALDI-MS

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Weyni Ghebreamlak; [2019]
   Keywords : Transferrin; Glycopeptides; Digestion; HPLC; MALDI-MS;

   Abstract : In this project, separation of trypsin digested transferrin (Tf) has been studied, using a RP HPLC- UV system equipped with a C18 column. 0.1% TFA/MQ-water and 90% MeOH were used as mobile phase A and mobile phase B, respectively. READ MORE

4. 3. Comparison of two HPLC columns: An attempt to improve analysis of carbohydrate-deficient transferrin

   University essay from Uppsala universitet/Institutionen för kvinnors och barns hälsa

   Author : Ida Engström; [2018]
   Keywords : Reprospher; liquid chromatography; ion exchange chromatography; CDT; gradient elution;

   Abstract : 1ABSTRACTCarbohydrate-deficient transferrin (CDT) is a biomarker for excessive and long-running intake of alcohol. It is a form of transferrin called disialotransferrin that under normal circumstances is <2 % of total transferrin in human blood. An increase is seen when alcohol consumption exceeds450 g per week. READ MORE

5. 4. Single-cycle kinetics for QCM biosensors for high throughput nanoparticle characterization application

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Fredrik Boström; [2016]
   Keywords : Single-cycle kinetics; kinetic titration; kinetics; image analysis; cell counting; nanoparticles; protein corona; method development; Multi-cycle kinetics; QCM biosensor;

   Abstract : Characterizing nanoparticles to be able to understand how they functions in the body is important for development of drugs. Furthermore with increasing number of nanoparticle product the nanotoxicity of nanoparticles is important to understand. READ MORE

6. 5. Comparison between four commonly used methods for detection of small M-components in plasma

   University essay from Institutionen för medicinsk biokemi och mikrobiologi

   Author : Susanne Jonsson; [2008]
   Keywords : Agarose gel electrophoresis; capillary electrophoresis; immunofixation; monoclonal immunoglobulin; multiple myeloma;

   Abstract : Analysis of M-components is an important part of the diagnosis of monoclonal gammopathies and for the evaluation of disease response during treatment. In this project, two widely used electrophoresis methods and their corresponding immunotyping method were compared to evaluate the sensitivity of each method for the detection of small M-components. READ MORE