Essays about: "WAC"

Showing result 1 - 5 of 6 essays containing the word WAC.

1. 1. Fermentation and germination of pearl millet and cowpea : a review of nutritional quality, antinutritionalcompounds and functional properties

   University essay from SLU/Department of Molecular Sciences

   Author : Stina Gustavsson; Sofia Jacobsson; [2020]
   Keywords : pearl millet; cowpea; fermentation; germination; chemical composition; antinutritional compounds; functional properties;

   Abstract : Undernutrition is responsible for 45% of deaths of children under the age of 5 in low- and middle-income countries, where pearl millet (Pennisetum glaucum) is one of the staple cereals. Despite of pearl millets favorable chemical composition, challenges still lie in the utilization of them due to the presence of antinutritional compounds (ANCs). READ MORE

3. 2. Fragment screening using WAC towards new SMARCA4 inhibitors

   University essay from Lunds universitet/Centrum för analys och syntes

   Author : Artur Sahakjan; [2020]
   Keywords : WAC; Fragments; SMARCA4; Library; Fragment Based Drug Discovery FBDD ; Peptide Synthesis; Affinity; Organic chemistry; Organisk kemi; Chemistry;

   Abstract : The drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been implemented into different techniques with purpose of discovering new drugs. READ MORE

4. 3. Peptide fragment screening towards a new inhibitor of neutrophil elastase

   University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

   Author : Tomas Szakacs; [2019]
   Keywords : pharmaceutical technology; läkemedelsteknologi; Chemistry; Technology and Engineering;

   Abstract : The main purpose of this master thesis was to test a novel approach of finding leads for new pharmaceuticals, by using Solid Phase Peptide Synthesis (SPPS) in combination with Weak Affinity Chromatography (WAC). Put in a more concrete way, the objective was to find a lead for a better human neutrophil elastase inhibitor. READ MORE

5. 4. The Birimian event in the Baoulé Mossi domain (West African Craton) : regional and global context

   University essay from Lunds universitet/Geologiska institutionen

   Author : Mikael Grenholm; [2014]
   Keywords : accretionary orogen; Atlantica; Birimian event; supercontinent cycle; Lomagundi-Jatuli event; Earth and Environmental Sciences;

   Abstract : The crystalline basement of the West African Craton (WAC) was established during the Siderian to Orosirian (circa 2.35-1.95 Ga) Birimian event through accretion of extensive tracts of juvenile crust that was tectonically juxtaposed with Archean cratons. READ MORE

6. 5. Evaluation of Rate Constants from Protein-Ligand Interactions with Weak Affinity Chromatography

   University essay from Institutionen för naturvetenskap, NV

   Author : Daniel Jönsson; [2012]
   Keywords : peak profile method; dissociation association rate constants; weak affinity chromatography; band-broadening;

   Abstract : The paradigm of drug discovery have been to find the strongest possible binder to the target by high-throughput screening (HTS) but high affinity interactions are related to low kinetic off rates and thus result in severe side-effects and non-approved drugs. Lead molecules working in a transient manner (KD > µM) will allow for rapid off rates and possibly less side-effects. READ MORE