Essays about: "Wnt"

Showing result 1 - 5 of 12 essays containing the word Wnt.

  1. 1. Actin filaments as an indicator of impaired neuronal differentiation mediated by disruption of the retinoic acid signalling pathway

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Hanin Salloum; [2022]
    Keywords : Retinoic acid; actin; cytoskeleton; neural progenitor C17.2 cells; neuron; Coronin 1C; Cdc42 Cdc42 effector protein 4 gene ; Fn1 Fibronectin ; Wnt pathway.;

    Abstract : Retinoic acid (RA) is a well-known neurodevelopmental signaling molecule. It is reported to induce effects on neurite formation in differentiating neurons and to interfere with the actin cytoskeleton. Therefore, this project aimed to investigate the mechanisms behind effects of RA on the actin cytoskeleton of developing neurons using the C17. READ MORE

  3. 2. Modelling of gene regulatory and spatial mechanisms which pattern the early human neural tube

    University essay from Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

    Author : Fredrik Bertilsson; [2022]
    Keywords : Biophysics; systems biology; gene regulatory networks; neural tube; isthmic organizer; midbrain-hindbrain boundary; WNT; FGF; morphogens; reaction-diffusion; finite-difference; 3D modelling; Physics and Astronomy;

    Abstract : Tissue patterning during development is thought to be driven largely by gene regulatory responses to spatial gradients of molecular signals, known as morphogens. In this thesis, early patterning of the human neural tube is studied using two different gene regulatory network models. READ MORE

  4. 3. Effects of a phthalate mixture on Wnt/β-catenin signaling, apoptosis and metabolic rate in zebrafish embryos

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Stavros Bountis; [2020]
    Keywords : phthalates; Wnt β-catenin signaling; apoptosis; zebrafish; metabolic rate;

    Abstract : One of the most common plasticizers used in the production of plastic are phthalates. These chemicals have been associated with many adverse effects including developmental and reproductive anomalies. Early developmental processes targeted by chemicals can have long-lasting effects on individuals. READ MORE

  5. 4. Patterning of the neural tube: A 3D computational modelling approach

    University essay from Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

    Author : Ariane Ernst; [2019]
    Keywords : gene regulatory networks; neural tube patterning; patterning of the neural tube; dopaminergic neurons; parkinson s disease; computational modelling; stem cell; GRN; Biology and Life Sciences; Physics and Astronomy;

    Abstract : Neurodegenerative diseases such as Parkinson’s can be treated with stem-cell derived specialized neurons. In order to achieve precise directed neural differentiation in vitro we need to understand the gene regulatory mechanisms behind in vivo neural tube patterning. READ MORE

  6. 5. The effect of DLG knockout, vitamin D and probiotic treatment on Drosophila gene expression

    University essay from Högskolan i Skövde/Institutionen för hälsa och lärande

    Author : Sophie Améen; [2018]
    Keywords : DLG; Drosophila melanogaster; Vitamin D; Probiotics; Colorectal cancer;

    Abstract : Background: Colorectal cancer is one of the most frequently diagnosed cancers today. Dlg is a tumor suppressor gene commonly silenced in cancer cells. Many colorectal cancer patients are subject to vitamin D3 deficiency and/ or an altered microbiome. READ MORE