Essays about: "Xenopus"

Showing result 1 - 5 of 7 essays containing the word Xenopus.

  1. 1. Characterization of diazepam binding inhibitor as a structure-function tool for human ɣ-aminobutyric acid-A receptors

    University essay from KTH/Proteinvetenskap

    Author : Szabolcs Simon-Guth; [2023]
    Keywords : γ-Aminobutyric acid sub-type A receptors; diazepam binding inhibitor; receptor modulation; recombinant protein expression; two-electrode voltage clamp; dose-response curve; Gammaaminosmörsyrareceptor typ A; Diazepambindande hämmare; receptormodulering; reckmbinant proteinexpression; spänningsklämma med två elektroder; dosresponskurva;

    Abstract : Gammaaminosmörsyrareceptorer typ A (GABAAR) är pentameriska ligandstyrda kloridkanaler som uppvisar neurohämmande egenskaper. Därmed är de primära läkemedelsmål för flera ångestdämpande och lugnande läkemedel som används för att minska förekomsten av aktionspotential i neuroner. READ MORE

  3. 2. Modulation of a model ligand-gated ion channel by amphetamine derivatives

    University essay from Uppsala universitet/Strukturbiologi

    Author : Emelia Karlsson; [2022]
    Keywords : pentameric ligand-gated ion channels; sTeLIC; electrophysiology; psychostimulants; amphetamine derivatives;

    Abstract : Pentameric ligand-gated ion channels are critical mediators of electrochemical signal transduction in neurons and other excitable cells, causing them to be important targets of psychoactive drugs. Structural data for these complex proteins are limited, particularly among eukaryotic family members and for the functionally critical open state. READ MORE

  4. 3. Effects of early life exposure to flutamide on sexual development in Xenopus tropicalis

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Miljötoxikologi

    Author : Christopher Hampton; [2019]
    Keywords : ;

    Abstract : While endocrine disrupting chemicals have become a serious concern in human and environmental toxicology, many of the methods used for investigating developmental toxicity require long exposure periods, and thus can be technically challenging, labour intensive and expensive. For example, the current standard method, the Larval Amphibian Growth and Development Assay (LAGDA) has an exposure period of ³130 days. READ MORE

  5. 4. Thyroid Endocrine Disruption of Propylparaben Assessed Using an Optimized Individual Xenopus tropicalis Metamorphosing Tadpole Exposure System

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Johannes Pohl; [2015]
    Keywords : Xenopus; Thyroid hormones; Endocrine disruption; Amphibian metamorphosis assay; Propylparaben; Hormonstörande ämnen; Propylparaben; Xenopus; Sköldkörtelhormoner;

    Abstract : The anuran Xenopus tropicalis tadpole is an attractive model animal in toxicological evaluation of suspected thyroid disrupting xenobiotics. Due to its reliance of a functioning hypothalamic-pituitary-thyroid (HPT) axis for normal metamorphosis, effects on the HPT axis produces apical endpoints, which are easy to measure. READ MORE

  6. 5. Gene expression, phylogenetic and syntenic analyses of pantophysin (Pan I) and synaptophysin-like2 (Sypl2) genes in Atlantic cod (Gadus morhua L.)

    University essay from SLU/Dept. of Animal Breeding and Genetics

    Author : Suzana Stjelja; [2012]
    Keywords : Gene expression; fish; evolution; phylogeny;

    Abstract : The pantophysin (Pan I) locus reveals differences between Norwegian coastal cod (NCC) and Northeast Arctic cod (NEAC) populations that are highly significant, temporally stable and larger than for any other genetic marker. However, the biochemical basis for the selection and the functional role of pantophysin in fishes are unknown. READ MORE