Essays about: "ZBED6"
Found 5 essays containing the word ZBED6.
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1. Characterization of DNA binding of the two zinc finger domains of transcription factor zBED6
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : The zinc finger protein, zBED6, is a transcriptional regulator of IGF2 along with hundreds of other genes relating to development and growth. Studies on the growth of commercially bred pigs discovered a single nucleotide substitution in the third intron of IGF2 which disrupts the binding of zBED6 and is responsible for the three-fold upregulation of IGF2 in skeletal muscle. READ MORE
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2. Identification of protein-interaction partners of ZBED6
University essay from SLU/Dept. of Animal Breeding and GeneticsAbstract : ZBED6 was recently discovered as a novel transcriptional repressor of IGF2 because a mutation disrupting one of its binding sites in porcine IGF2 intron 3 leads to greater postnatal IGF2 expression in skeletal muscle and makes pig grow more muscle. ZBED6 is unique to placental mammals and derived from domesticated DNA transposon. READ MORE
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3. ZBED6 expression pattern during embryogenesis and in the central nervous system
University essay fromAbstract : .... READ MORE
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4. Bioinformatics analysis of ZBED6, a novel transcription factor in mammals
University essay from SLU/Dept. of Animal Breeding and GeneticsAbstract : The identification of a regulatory mutation in the intron 3 of Insulin like growth factor 2, was a major finding. This single nucleotide mutation in the non coding region abrogates the interaction of nuclear factor ZBED6, resulting in the 3-4% increase in the muscle mass of domesticated pigs. READ MORE
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5. Bioinformatics analysis of ZBED6 : interactome of Novel Transcription Factor ZBED6 in C2C12 Myoblasts
University essay from SLU/Dept. of Animal Breeding and GeneticsAbstract : ZBED6 is a novel mammalian transcription factor that was recently identified and shown to act as a repressor of IGF2 transcription in skeletal muscle. Chromatin Immunoprecipitation (ChIP) sequence data in murine C2C12 myoblasts indicated that ZBED6 holds 2499 targeting sites. READ MORE
