Essays about: "adverse reactions"

Showing result 1 - 5 of 49 essays containing the words adverse reactions.

  1. 1. Utilizing Transformers with Domain-Specific Pretraining and Active Learning to Enable Mining of Product Labels

    University essay from Uppsala universitet/Avdelningen för beräkningsvetenskap

    Author : Erik Norén; [2023]
    Keywords : Machine Learning; Natural Language Processing; NLP; BERT; Active Learning; AL; Pharmacovigilance; UMC; Uppsala Monitoring Centre; Structured Product Label; SPL; Transformers; Domain-Specific Pretraining; NER; Named Entity Recognition; Adverse Drug Reaction; ADR;

    Abstract : Structured Product Labels (SPLs), the package inserts that accompany drugs governed by the Food and Drugs Administration (FDA), hold information about Adverse Drug Reactions (ADRs) that exists associated with drugs post-market. This information is valuable for actors working in the field of pharmacovigilance aiming to improve the safety of drugs. READ MORE

  3. 2. Synthesis and analysis of potential metabolites of ADB-5´Br-BUTINACA

    University essay from Linköpings universitet/Kemi

    Author : Alaa Malekshahineia; [2023]
    Keywords : metabolites; NPS; synthetic cannabinoids;

    Abstract : In recent years, there has been a rise in the use of New Psychoactive Substances (NPS) that mimic the effects of controlled drugs and licensed medicines, which have become a significant public health concern globally. Synthetic cannabinoids, a rapidly expanding category of NPS, with much higher potency and binding affinity to the cannabinoid receptors than ∆9-tetrahydrocannabinol (THC), have led to serious psychiatric complications and other adverse effects. READ MORE

  4. 3. Utgör exponering för exogent östrogen en fara för våra sällskapdjur?

    University essay from SLU/Dept. of Clinical Sciences

    Author : Sandra Friberg; Ulrika Svedman; [2022]
    Keywords : biverkning; hund; hyperöstrogenism; katt; sekundär exponering; transdermal; östrogenbehandling;

    Abstract : Läkemedelsverket har fått in ett fåtal rapporter angående biverkningar hos sällskapsdjur som exponerats för transdermal östrogenbehandling som använts av djurägaren. Human användning av östrogenpreparat vid exempelvis klimakteriebesvär eller könskorrigering ökar. READ MORE

  5. 4. Free-text Informed Duplicate Detection of COVID-19 Vaccine Adverse Event Reports

    University essay from Uppsala universitet/Avdelningen för systemteknik

    Author : Erik Turesson; [2022]
    Keywords : Duplicate detection; Deduplication; Record linkage; Adverse Event Reports; COVID-19 Vaccines; Uppsala Monitoring Centre; VigiBase; Machine Learning; Gradient Boosted Decision Trees; BERT; Natural Language Processing; Pharmacovigilance; Individual Case Safety Reports;

    Abstract : To increase medicine safety, researchers use adverse event reports to assess causal relationships between drugs and suspected adverse reactions. VigiBase, the world's largest database of such reports, collects data from numerous sources, introducing the risk of several records referring to the same case. READ MORE

  6. 5. 3′-end fluorescence labelling of long RNAs using terminal deoxynucleotidyl transferase

    University essay from Lunds universitet/Kemiska institutionen

    Author : Johannes Lidberg; [2022]
    Keywords : Physical biochemistry; Fluorescence; In vitro transcription; RNA; Terminal deoxynucleotidyl transferase; Nucleobase analogue; Chemistry;

    Abstract : Through recent years, RNA has rapidly gone from mainly being known as a passive information-carrying molecule within the central dogma of molecular biology to becoming the active ingredient in multiple therapeutics, such as in vaccines and potential drugs against cancer. However, one of the main challenges with RNA as a therapeutic is efficient delivery to cells. READ MORE