Essays about: "albumin binding domain"

Showing result 1 - 5 of 7 essays containing the words albumin binding domain.

1. 1. Generation of a new ADAPT library for stability improvement

   University essay from KTH/Proteinvetenskap

   Author : Sumant Yogesh Salphale; [2023]
   Keywords : Phage display; CEACAM5; EpCAM; Trop2; ADAPT; ABD; protein engineering; cancer detection; Fag-display; CEACAM5; EpCAM; Trop2; ADAPT; ABD; proteinteknik; cancerdetektion;

   Abstract : Under senare år har målinriktad terapi varit ett växande område inom cancerterapi som en mer målinriktad behandling än kemoterapi. Dessa behandlingar baseras främst på antikroppsbaserade läkemedel som är ganska stora och komplexa, vilket ökar den totala kostnaden för behandlingen. READ MORE

3. 2. Characterization of novel bispecific ADAPTs selected for cancer-related targets

   University essay from KTH/Proteinvetenskap

   Author : Blenda Hedin; [2021]
   Keywords : cancer therapy; alternative administration routes; ADAPT; ABD; protein technology; albumin; simultaneous bispecificity; CCL7; CEACAM5; VEGF-A;

   Abstract : Cancer is still one of the most common causes of death world-wide and in parallel there is a need to update the repertoire of therapies that withstand resistance of recurrent cancers. Since the introduction of antibody therapies as anti-cancer pharmaceuticals, recognized as immunotherapy in health care, it has been an increasing field in cancer therapy, as a more targeted treatment compared to chemotherapy. READ MORE

4. 3. Production and Evaluation of a Bombesin Analogue Conjugated to the Albumin-Binding Domain and DOTA for Prostate Cancer Radiotherapy

   University essay from KTH/Proteinvetenskap

   Author : Fredrika Landmark; [2021]
   Keywords : bombesin; prostate cancer; radiotherapy; human serum albumin; half-life extension; bombesin; prostatacancer; radioterapi; humant serumalbumin; halveringstidsförlängning;

   Abstract : Prostate cancer is one of the most common types of cancer worldwide and claims hundreds of thousands of lives annually. Currently the most common treatment for prostate cancer is external beam radiotherapy, however, this treatment comes with serious side effects since it lacks selectivity for the cancer cells. READ MORE

5. 4. Investigation of possible improvements of the stability of bispecific ADAPT proteins

   University essay from KTH/Proteinvetenskap

   Author : Ella Eriksson; [2021]
   Keywords : Protein purification; Affinity chromatography; ABD-derived domain; ADAPT protein; simultan binding;

   Abstract : The aim of the project was to identify positions and amino acids that contribute to improved structure and stability of bispecific ADAPT proteins. During the 20 weeks project period, different amino acid substitutions were analysed to evaluate the effect on the three-helical structure and stability of bispecific ADAPTs targeting human serum albumin (HSA) and tumor necrosis factor α (TNFα). READ MORE

6. 5. Selection and characterization of bispecific ADAPT molecules for enhanced biodistribution in cancer therapy

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Jesper Borin; [2020]
   Keywords : ABD; ADAPT; HER2; CEACAM6; HSA; Phage display; Cancer therapy; Spatial bispecificity; Half-life extension; Biodistribution;

   Abstract : Established biopharmaceuticals such as antibodies and derivatives thereof are relatively large. In cancer therapy, this creates a steep drug concentration gradient within tumors, leaving cells far from blood vessels effectively untreated. READ MORE