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Showing result 1 - 5 of 18 essays matching the above criteria.

  1. 1. Predicting Protein Stability with Machine Learning

    University essay from Lunds universitet/Biofysikalisk kemi

    Author : Lucas Carlsson; [2023]
    Keywords : Protein Stability; Biophysical Chemistry; Thermodynamics; Machine Learning; Deep Learning; Protein Language Model; Biochemistry; Multiple Sequence Alignment; Bioinformatics; Biology and Life Sciences;

    Abstract : Protein stability is a property of high importance and is of interest in a variety of fields. It determines if a protein has its native fold and can be of influence in certain diseases such as Parkinson's and Alzheimer's disease. READ MORE

  3. 2. Effect of DNAJB6 on α-synuclein amyloid fibril aggregation and dis-aggregation

    University essay from Lunds universitet/Biofysikalisk kemi

    Author : Josef Getachew; [2023]
    Keywords : α-synuclein; alpha-synuclein; chaperones; DNAJB6; the unhappy chaperone; parkinsons disease; biophysical chemistry; biochemistry; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Abstract : Amyloid proteins are a group of proteins with the ability to form large fibrillar aggregates, identifiable by their cross-β core structure. These aggregates are linked to several different neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease and due to the growing rate of people diagnosed, there is a need to combat these diseases. READ MORE

  4. 3. Application of Biomimetic Membrane Models in Expansion Microscopy

    University essay from KTH/Proteinvetenskap

    Author : Praghadhesh Thiagarajan; [2023]
    Keywords : Fluorescence microscopy; expansion microscopy; GPMV; inter-leaflet asymmetry; Fluorescensmikroskopi; expansionsmikroskopi; GPMV; asymmetri mellan lagren;

    Abstract : Plasmamembranet är en komplex struktur som består av biomolekyler som lipider, proteiner och glykaner. Membranets rena komplexitet begränsar vår förmåga att förstå den spatiotemporala dynamiken hos sådana komponenter och deras kollektiva biofysiska membranparametrar. READ MORE

  5. 4. Optimizing the Production of Aurora Kinase A and Validation of Constructs with different Sequential Lengths

    University essay from Linköpings universitet/Kemi

    Author : Linnea Pierre; [2022]
    Keywords : Protein; Protein chemistry; Aurora Kinase A; Aurora A; Cancer; Structural Biology; Cancer research;

    Abstract : Aurora Kinase A is a kinase involved in multiple signaling pathways and interactions during mitosis, making it an essential kinase that deregulated causes cancer diseases in affected patients. Structural research shows mainly static snapshots of possible conformations of the partly disordered protein. READ MORE

  6. 5. Aromatic Ring Flips and Local Volume Fluctuations in BPTI

    University essay from Lunds universitet/Biofysikalisk kemi

    Author : Simon Enbom; [2022]
    Keywords : Biophysical Chemistry; Molecular Dynamics; Protein Dynamics; Activation Volume; Aromatic Ring Flips; BPTI; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Abstract : Aromatic ring flips are a classic example of a dynamic process in proteins. Discovered decades ago, methodological limitations hindered progress at the time. Ring flips have gained new interest and experimentalists can measure the flip rate and thermodynamic quantities associated with it. READ MORE