Essays about: "blood-brain-barrier"
Showing result 1 - 5 of 31 essays containing the word blood-brain-barrier.
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1. P-glykoprotein-mutationen - ABCB1-1Δ hos collies i Sverige
University essay from SLU/Dept. of Anatomy, Physiology and BiochemistryAbstract : P-glykoprotein är ett effluxprotein som uttrycks på olika luminala ytor i flera organ, bland annat tarmväggen, njurtubuli, i leverns gallgångar samt i blodhjärnbarriären. Proteinet kodas av genen ABCB1 hos hund. READ MORE
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2. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants
University essay from Uppsala universitet/Institutionen för farmaciAbstract : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. READ MORE
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3. Design and production of adeno-associated virus vectors for imaging mitochondrial networks in the brain
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Mitochondria are dynamic organelles that function in a complex interconnected network within the cell. Neurons are sensitive and highly energy demanding cells in the brain which require a functioning mitochondrial network that is able to provide ATP and modulate calcium. READ MORE
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4. The Potential Use of Degradable Starch Microspheres as a Carrier for Nasal Drug Administration
University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)Abstract : Intranasal drug delivery is a practical and accessible method for treating localized symptoms as well as achieving systemic drug absorption. The approach takes advantage of the permeability, vascularization, and limited enzymatic activity of nasal tissue, leading to enhanced drug absorption. READ MORE
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5. Design, synthesis, and evaluation of 1-phenylethanol and C2 threitol derivatives as non-pyranose galactose-mimicking inhibitors of Galectin-3
University essay from Lunds universitet/Centrum för analys och syntesAbstract : Galectins are cytosolic protein family involved in several biological functions such as cell differentiation, cell migration and apoptosis amongst many others. Their presence is also substantial in diseases including acute inflammation, fibrosis, allergies, and cancer. READ MORE