Essays about: "cancer cell line"

Showing result 11 - 15 of 59 essays containing the words cancer cell line.

  1. 11. Systems biology of deregulated splicing in cancer. A pan-cancer analysis of dysfunctional splicing machinery and alternative splicing events.

    University essay from

    Author : Leticia Castillon; [2021-08-06T14:57:24Z 2021-08-06T14:57:24Z 2021 2020]
    Keywords : multi-omics; splicing; alternative splicing; deep learning; cancer; transcriptome;

    Abstract : The deregulation or disruption of the splicing process has been shown to play a role in the onset, development, and even response to treatment of some malignancies. Partly due to our incomplete understanding of the mechanism and regulation behind splicing and alternative splicing, the importance of aberrant splicing in oncogenesis is not yet understood. READ MORE

  3. 12. Characterization of a novel EPHB2 R155C mutant with respect to its proteolytic cleavage by TF/FVIIa

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Ece Akcan; [2021]
    Keywords : cancer; colorectal cancer; CRC; ephrin receptor; EPHB2; tissue factor; TF; TF FVIIa; cleavage; cell repulsion;

    Abstract : EPHB2, an ephrin receptor (EPH) from receptor tyrosine kinase (RTK) family, is one of the substrates for tissue factor (TF) - coagulation factor VIIa (FVIIa) complex and it is cleaved in its ectodomain. EPHB2 cleavage is important for ephrin receptor (EPH) - ephrin ligand (EFN) signaling and cell repulsion. READ MORE

  4. 13. Extracellular vesicles (EVs):roles in cell proliferation and transcriptomic analysis of HUVEC receiving cancerderived EVs

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Benyapa Tangruksa; [2021]
    Keywords : ;

    Abstract :  Extracellular vesicles (EVs) are released by almost  all types of cells. EVs play an    important role in cell-to-cell communication by sending biomolecules such as mRNAs to    other cells via endocytosis. READ MORE

  5. 14. Validation of a 3D culture model for toxicity studies in malignant and non-cancerous cells

    University essay from Lunds universitet/Institutionen för immunteknologi

    Author : Kajsa Andreasson Dahlgren; [2021]
    Keywords : Dose-response; potency; in vitro; 2D model; 3D model; cancer; MEK inhibitor; trametinib; A549; LL47; Western blot; Biology and Life Sciences;

    Abstract : Cancer is a widespread and commonly fatal disease in constant need of new treatments. Traditionally, new pharmaceuticals have been tested in 2D models. This is not ideal, as 2D environments do not reflect the in vivo milieu of the cells. READ MORE

  6. 15. Expression of the Sloppymerase™ in NIH/3T3 Cells: Exploring the Versatility of an Error Prone Fusion Polymerase

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Mikaela Mattsson; [2021]
    Keywords : ;

    Abstract : The aim of this project is to assess the versatility of the Sloppymerase by performing stable transfection in NIH/3T3 cells and decide whether this cell line can be a candidate for further research on the Sloppymerase as a cancer model. The American cancer society predicts 1,806,590 new cancer cases in the US in 2020. READ MORE