Essays about: "circular dichroism"

Showing result 1 - 5 of 21 essays containing the words circular dichroism.

  1. 1. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    University essay from Uppsala universitet/Theranostics

    Author : Astrid Haraldsson; [2023]
    Keywords : PNA; pretargeting; cancer therapy; cytotoxic payload;

    Abstract : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. READ MORE

  3. 2. Characterisation of structure and stability differences between the C-lobes of human and P. falciparum calmodulin in the presence of calmidazolium

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Igor Blagojevic; Klara Enockson; Marcus Miras Landelius; Ylva Strid Holmertz; Emelie Weinesson; Emma Örnelöw; [2022]
    Keywords : Calmodulin; Calmidazolium; Plasmodium falciparum; Malaria; Fluorescence spectroscopy; UV spectroscopy; CD; Circular dichroism; bioinformatics;

    Abstract : Malaria is a serious disease that can lead to fatal consequences if not treated. It is mainly spread via Plasmodium falciparum, a parasite carried by mosquitoes as host organisms. As a potential way of treating malaria, research is being done on possible inhibitors of calmodulin (CaM) in the parasite. READ MORE

  4. 3. Investigation of the function of the SH3-like domain of the Saccharopolyspora erythraea iron-dependent regulator

    University essay from Uppsala universitet/Institutionen för kemi - BMC

    Author : Carita Hammar; [2022]
    Keywords : ;

    Abstract : The bacterium Saccharopolyspora erythraea is utilized to produce the widely used antibiotic erythromycin. With the increasing problem of antibiotic resistance, the development of derivatives of the drug is of great importance. To produce antibiotics biosynthetically, it is crucial to understand the metabolic pathways utilized by the bacterium. READ MORE

  5. 4. Production and Evaluation of a Bombesin Analogue Conjugated to the Albumin-Binding Domain and DOTA for Prostate Cancer Radiotherapy

    University essay from KTH/Proteinvetenskap

    Author : Fredrika Landmark; [2021]
    Keywords : bombesin; prostate cancer; radiotherapy; human serum albumin; half-life extension; bombesin; prostatacancer; radioterapi; humant serumalbumin; halveringstidsförlängning;

    Abstract : Prostate cancer is one of the most common types of cancer worldwide and claims hundreds of thousands of lives annually. Currently the most common treatment for prostate cancer is external beam radiotherapy, however, this treatment comes with serious side effects since it lacks selectivity for the cancer cells. READ MORE

  6. 5. Investigation of possible improvements of the stability of bispecific ADAPT proteins

    University essay from KTH/Proteinvetenskap

    Author : Ella Eriksson; [2021]
    Keywords : Protein purification; Affinity chromatography; ABD-derived domain; ADAPT protein; simultan binding;

    Abstract : The aim of the project was to identify positions and amino acids that contribute to improved structure and stability of bispecific ADAPT proteins. During the 20 weeks project period, different amino acid substitutions were analysed to evaluate the effect on the three-helical structure and stability of bispecific ADAPTs targeting human serum albumin (HSA) and tumor necrosis factor α (TNFα). READ MORE