Essays about: "degradants"

Found 2 essays containing the word degradants.

1. 1. Development and validation of an ultrahigh-performance liquid chromatography method for identity, assay and impurity testing of nicotine and preservatives in nicotine nasal spray

   University essay from Lunds universitet/Centrum för analys och syntes

   Author : Amane Kandas; [2021]
   Keywords : Nicotine; Nicotine nasal spray; Ultrahigh-performance liquid chromatography; Development; Validation; Technical analytical chemistry; Chemistry;

   Abstract : The topic of this study is to develop and validate an analysis method of nicotine nasal spray produced at McNeil AB. When developing the analysis method, several parameters were determined in advance to make the method more similar to other analysis methods at the company, making it more practical. READ MORE

3. 2. Evaluation of a UPLC-MS method using 18O-labelled water for the identification of hydrolytic degradants of drug substances

   University essay from Uppsala universitet/Avdelningen för analytisk farmaceutisk kemi

   Author : Viktor Kjellberg; [2015]
   Keywords : hydrolysis; degradation; degradants; 18O; 18O-water; liquid chromatography; mass spectrometry; analytical chemistry; structure eludication;

   Abstract : In this master’s thesis the hydrolytic degradation in 18O-water solutions of six drug substances has been studied. The aim was to develop a mass spectrometric method for easier identification of degradants, since hydrolysis in 18O-water will generate degradants with higher mass compared with hydrolysis in regular water. READ MORE