Essays about: "determination drug"

Showing result 1 - 5 of 12 essays containing the words determination drug.

  1. 1. Content determination of explosive precursors and narcotic salts using 35Cl-nuclear magnetic resonance

    University essay from Örebro universitet/Institutionen för naturvetenskap och teknik

    Author : Sandra Bergqvist; [2023]
    Keywords : Nuclear magnetic resonance NMR ; explosive precursors; narcotic salts; method validation.;

    Abstract : Explosive precursors and narcotic salts are chemicals contributing to an undesirabledevelopment of the Swedish society, both in terms of criminal activities and harm to the environment. Reducing the illegal use of these chemicals is important in the work towards a safer society. READ MORE

  3. 2. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus

    University essay from Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Author : Elin Öberg; [2022]
    Keywords : x-ray crystallography; protein crystallization; Venezuelan equine encephalitis virus; structure-based drug design; applied biochemistry; Technology and Engineering;

    Abstract : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. READ MORE

  4. 3. The Role of Endoplasmic Reticulum Stress and Hepatic Stellate Cells in Inducing Chemoresistance in Hepatocellular Carcinoma

    University essay from Uppsala universitet/Institutionen för medicinsk cellbiologi

    Author : Jaafar Khaled; [2021]
    Keywords : Hepatocellular carcinoma; ER-stress; hepatic stellate cells; chemoresistance; doxorubicin; 4μ8C; Hepatocellulärt karcinom; ER-stress; hepatiska stellatceller; kemoresistens; doxorubicin; 4μ8C;

    Abstract : Hepatocellular carcinoma (HCC) is the most common liver malignancy that usually develops in patients suffering from chronic liver diseases. One of the major problems faced in the treatment of HCC is severe chemoresistance. READ MORE

  5. 4. In silico and in vitro determination of substrate specificity for Breast Cancer Resistance Protein (BCRP) transporter at the blood-brain barrier

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Fen Wang; [2021]
    Keywords : BCRP; substrate specificity; BBB; ATP-binding cassette ABC transporter; Drug transport;

    Abstract : Background The Breast Cancer Resistance Protein (BCRP) drug transporter is important for drug disposition and plays a critical role in regulating drug entry into the brain. Its substrate spectrum overlaps with substrates of Multi Drug Resistance Protein 1 (MDR1, P-gp), which influences and complicates the interpretation of data on drug distribution into tissues (e. READ MORE

  6. 5. Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma

    University essay from KTH/Tillämpad fysikalisk kemi

    Author : Leona Clarin; [2020]
    Keywords : Unbound concentration; free concentration; ultrafiltration; LC-MS MS; cefotaxime; flucloxacillin; cloxacillin; piperacillin; Fri fraktion; ultrafiltrering; LC-MS MS; cefotaxim; flukloxacillin; kloxacillin; piperacillin;

    Abstract : Infections in critically ill patients are a problem for the healthcare system and at any one time, 70 % of all intensive care unit (ICU) patients are treated with antibiotics. Antibiotics bind toproteins in the blood, but only unbound drug can diffuse over capillary membranes and bindto the targeted receptor. READ MORE