Essays about: "dissociation constant Kd"
Showing result 1 - 5 of 6 essays containing the words dissociation constant Kd.
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1. Biophysical characterization of and screening for binders and potentiator compounds that modulate the binding of PDZ domains to the C-terminal peptide motifs of target proteins
University essay from KTH/ProteinvetenskapAbstract : The N-methyl-D-aspartate receptor (NMDAR) hypofunctional hypothesis is believed to explain one of the contributing factors to schizophrenia. This hypothesis suggests the dysregulation of NMDAR, a protein responsible for receiving signals from the synapses between neurons, is the cause of some of the symptoms seen in schizophrenia. READ MORE
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2. Fragment screening using WAC towards new SMARCA4 inhibitors
University essay from Lunds universitet/Centrum för analys och syntesAbstract : The drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been implemented into different techniques with purpose of discovering new drugs. READ MORE
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3. Interactions of the Human Recombinant Proteins JUNO and IZUMO1
University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)Abstract : Det uppskattas att 15% av alla par världen över lider avinfertilitet. Ungefär hälften beror på manlig infertilitet och 40% av dessa fall kan ännu inte förklaras. Därmed är nuvarande metoder för att diagnostisera manlig infertilitet otillräckliga och ytterligare tekniker behövs. READ MORE
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4. Modelling antibody orientation at bacterial surfaces
University essay from Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisationAbstract : Bacteria and humans have co-evolved since their common existence. They have thereby developed very specific defence and target mechanisms against one another. Understanding the complex biomolecular processes behind these interactions can be of great use for developing treatments against bacterial diseases. READ MORE
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5. Structure and function of a bacterial redox sensor.
University essay from Lunds universitet/Kemiska institutionenAbstract : Gram-positive bacteria e.g. Streptomyces coelicolor [8], Bacillus subtilis [43] and Staphylococcus aureus [40] contain a novel sensor for the nicotinamide adenine dinucleotide (NAD) redox balance that functions as a transcriptional repressor called Rex (redox). Rex plays a key role in regulating genes in energy metabolism. READ MORE