Essays about: "fab"

Showing result 1 - 5 of 12 essays containing the word fab.

  1. 1. Graph Bandits : Multi-Armed Bandits with Locality Constraints

    University essay from KTH/Skolan för elektroteknik och datavetenskap (EECS)

    Author : Kasper Johansson; [2022]
    Keywords : Multi-armed bandits; locality constraints; reinforcement learning; Flerarmade banditer; lokala restriktioner; förstärkningsinlärning;

    Abstract : Multi-armed bandits (MABs) have been studied extensively in the literature and have applications in a wealth of domains, including recommendation systems, dynamic pricing, and investment management. On the one hand, the current MAB literature largely seems to focus on the setting where each arm is available to play at each time step, and ignores how agents move between the arms. READ MORE

  3. 2. A comparison of different orthogonal techniques for the investigation of the conformational stability of NIST mAb in liquid formulations

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Madeleine Andersson; [2020]
    Keywords : Pharmaceutical technology; Läkemedelsteknologi; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Abstract : A great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. READ MORE

  4. 3. Development and comparison of bioanalytical methods to measure free analyte

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Alma Pihlblad; [2020]
    Keywords : Biotechnology; immunoassay; Gyrolab; ELISA; immunology; free analyte; overestimation; affinity; Avastin; bevacizumab; Lucentis; ranibizumab; VEGF; pharmacokinetic; pharmacodynamic;

    Abstract : Free analyte is measured to be able to understand the pharmacological effects of a drug in the body, the binding to its ligand, and the effective drug level among other things. Thereby, it is important with correct measurements of free analyte, although it is not that easy to achieve since overestimations can occur. READ MORE

  5. 4. Calcium-dependent affinity ligands for protein purification

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Emma Larsson; [2020]
    Keywords : Purification; Affinity chromatography; Protein A; Z domain; Calcium-dependent; ZCa; Elution;

    Abstract : The rapid growth of the biopharmaceutical industry has led to increasing demands on the protein production process. An important aspect is the yield of functional protein, which can be greatly affected by the choice of downstream purification. READ MORE

  6. 5. Drugs of the Future - Bispecific Antibodies : An investigaion of future development needs

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Carl Fabian Svahn; Anisha Khan; Amanda Wahlsten; Terese Larsson; Therese Koivula; Thomas Andersson; [2019]
    Keywords : bispecific; antibodies; antibody; production; preclinical; clinical; development; knob-into-hole; Duetmab; crossmab; beat; orthogonal; fab;

    Abstract : This report reviews the field of bispecific antibodies, artificially engineered antibodies thathave the ability to bind two or more different antigen simultaneously. Historical as well asrecently developed techniques are demonstrated, together with formats in preclinical andclinical development. READ MORE