Essays about: "gemcitabine."

Showing result 1 - 5 of 6 essays containing the word gemcitabine..

  1. 1. Combining doxorubicin and gemcitabine with targeted drugs as a treatment option for high-risk neuroblastoma

    University essay from KTH/Proteinvetenskap

    Author : Alexandra Johannesson; [2023]
    Keywords : neuroblastoma; doxorubicin; gemcitabine; targeted drugs; ATM; neuroblastom; doxorubicin; gemcitabin; målinriktade läkemedel; ATM;

    Abstract : Neuroblastom är en barncancer som uppstår ur det sympatiska nervsystemet och drabbar omkring 15 barn i Sverige varje år. Högriskvarianten är associerad med mycket hög dödlighet och risk för återfall, vilket tros ha att göra med att tumörernas ovanligt heterogena sammansättning tillåter resistenta subpopulationer att motstå konventionella behandlingsmetoder. READ MORE

  3. 2. Combination of Antimetabolites with Chemotherapy as a Novel Treatment Option in High-risk Neuroblastoma

    University essay from KTH/Proteinvetenskap

    Author : Maja Lundström; [2022]
    Keywords : cell cycle arrest; chemotherapy resistance; combination therapy; cytarabine; doxorubicin; gemcitabine;

    Abstract : 20 svenska barn diagnostiseras årligen med barntumören neuroblastom (NB). Läkemedelsresistens och intratumoral heterogenitet försvårar behandlingen och 50-60% av hög-risk NB-patienter drabbas av återfall. Subpopulationer av resistenta celler har identifierats i hög-risk NB-cellinjer, vilket belyser behovet av nya behandlingsalternativ. READ MORE

  4. 3. Building a genomic variant based prediction model for lung cancer toxicity

    University essay from KTH/Tillämpad fysik

    Author : Vincent Janvid; [2021]
    Keywords : cancer; bioinformatics; genomics; cancer; bioinformatik; genomik;

    Abstract : Since the completion of the the Human genome project in 2003, the evident complexity of our genome and its regulation has only grown. The idea that having sequenced the human genome would solve this mystery was quickly discarded. READ MORE

  5. 4. Knockout studies of Panc1 cells

    University essay from KTH/Tillämpad fysik

    Author : Martin Sundin; [2021]
    Keywords : PDAC; crosstalk; stroma; spheroid; western blot; viability; gemcitabine.; PDAC;  verh rning; stroma; sf roid; western blot; viabilitet; gemcitabine.;

    Abstract : Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancerwith very few available treatment options of which none has great effect.Cancer cells and stromal cells such as stellate cells which exist in abundancein PDAC interact by crosstalk, resulting in a tumorigenic collective response. READ MORE

  6. 5. Circumventing Gemcitabine resistance in pancreatic cancer using drug delivery systems

    University essay from Lunds universitet/Examensarbeten i molekylärbiologi

    Author : Gabriella Willman; [2017]
    Keywords : Biology and Life Sciences;

    Abstract : Gemcitabine is the first line treatment of pancreatic cancer, a treatment that is relying on the expression of human Equilibrative Nucleoside Transporter 1 for cellular uptake. Combined with its short blood half-life and intracellular activation steps, Gemcitabine treatment has many limitations. READ MORE