Essays about: "gene regulatory networks"
Showing result 1 - 5 of 14 essays containing the words gene regulatory networks.
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1. Inferring Gene regulatory networks using Graph Neural Networks
University essay from KTH/GenteknologiAbstract : Inom beräkningsbiologin är det snabbt på väg att bli allt vanligare att ta fram genetiska regleringsnätverk (GRN). På grund av storleken på de undersökta nätverken använder många forskare maskininlärning för att härleda GRN från genuttrycksdata, vanligtvis från RNA-seq. READ MORE
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2. Capturing genes with high impact based on reconstruction errors produced by variational autoencoders
University essay from Högskolan i Skövde/Institutionen för biovetenskapAbstract : In this work we present a novel method to extract potential hub genes, transcription factors and regions with densely interconnected protein-protein-interaction networks from RNAseq data. To achieve this we deploy variational autoencoders, a generative machine learning framework, and extract the gene-wise reconstruction errors. READ MORE
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3. Imputing connections of random gene networks from time series data using ANNs
University essay from Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisationAbstract : This thesis presents the architecture of a convolutional neural network which is trained to impute the connections of randomly generated gene regulatory networks under varying amounts of regularisation. The generated gene networks are simulated from 10 different starting conditions for each set of connections in order to obtain multiple time series. READ MORE
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4. Modelling of gene regulatory and spatial mechanisms which pattern the early human neural tube
University essay from Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisationAbstract : Tissue patterning during development is thought to be driven largely by gene regulatory responses to spatial gradients of molecular signals, known as morphogens. In this thesis, early patterning of the human neural tube is studied using two different gene regulatory network models. READ MORE
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5. Patterning of the neural tube: A 3D computational modelling approach
University essay from Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisationAbstract : Neurodegenerative diseases such as Parkinson’s can be treated with stem-cell derived specialized neurons. In order to achieve precise directed neural differentiation in vitro we need to understand the gene regulatory mechanisms behind in vivo neural tube patterning. READ MORE
