Essays about: "glycan"

Showing result 1 - 5 of 8 essays containing the word glycan.

  1. 1. Exploring a unique pocket in Galectin-8N by the synthesis of D-galactoside-based benzimidazole inhibitors

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Sid Bartold; [2023]
    Keywords : organic chemistry; synthesis; gal; gal-8; gal-8N; galectin; galectin-8; galectin-8N; inhibitor; drug development; benzimidazole; galactoside; carbohydrate; carbohydrate chemistry; Suzuki-coupling; Chemistry;

    Abstract : Galectins are a family of glycan-binding proteins where galectin-8 is a part of the subgroup known as tandem-repeat type galectins. Galectin-8 is composed of two homologous CRDs, one N- and one C-terminal CRD. As it stands now, galectin-8N has been found to bind to a larger number of glycans than galectin-8C. READ MORE

  3. 2. Finding the Sweet Spot

    University essay from Göteborgs universitet/Institutionen för data- och informationsteknik

    Author : VIKTORIA KARLSSON; [2022-06-29]
    Keywords : Glycans; glycome; cancer; tumor; machine learning; bioinformatics; data science; thesis;

    Abstract : Complex carbohydrates, or glycans, are involved in cancer progression and could thereby serve as diagnostic markers as well as therapeutic targets. However, new research is required to determine which glycan motifs are universal signatures of tumor environments. READ MORE

  4. 3. Oligosaccharide Analysis - Assessment of the DNS Method and Specification of Glucans Processed with CGTase

    University essay from Lunds universitet/Bioteknik; Lunds universitet/Bioteknik (master)

    Author : Matilda Johansson; [2022]
    Keywords : CGTase; DNS; Chromatography; HPAEC; HPAE; Carbohydrate; Carbohydrates; Glucans; Cyclodextrin glycosyltransferase; Biotechnology; Bioteknik; Flory; Enza; Enzyme; Technology and Engineering;

    Abstract : In this study, the reagent 3,5-dinitrosalicylic acid (DNS) and high-performance anion exchange chromatography (HPAEC) were used for carbohydrate characterisation. It was revealed that the DNS reaction is not exclusive to reducing ends as commonly thought, but rather that the reagent reacts with other parts of the carbohydrate molecules as well. READ MORE

  5. 4. Effects of antibody labeling chemistry on assays developed for the Gyrolab immunoassay platform

    University essay from Uppsala universitet/Molekylär systembiologi

    Author : Julia Dencker; [2021]
    Keywords : Antibodies; Labeling chemistry; Site-specific labeling; Immunoassay; Gyrolab;

    Abstract : The aim of this project was to make a comparison of the effects of antibody labeling chemistries on assays developed for the Gyrolab immunoassay platform. One of the labeling techniques was a heterogenous labeling technique targeting amino groups on the antibody. READ MORE

  6. 5. Synthesis of bioactive compounds: Synthetic study of D-Lac-terminated peptidoglycan fragment structures

    University essay from KTH/Kemiteknik

    Author : Yu Saito; [2021]
    Keywords : organic synthesis; peptidoglycan; lactate; glycopeptide; solid-phase peptide synthesis; organisk syntes; peptidoglycan; laktat; glykopeptid; fastfas-peptidsyntes;

    Abstract : Peptidoglycan (PGN) är en bakteriecellväggskomponent och känd för att känna igen olika receptorer eller enzymer för att leda aktiveringsimmunsystemet. Den allmänna strukturen för PGN består av sockerkedjor inklusive N-acetylglutamin (GlcNAc), N-acetylmuraminsyra (MurNAc) och tvärbundna peptidkedjor. READ MORE