Essays about: "in silico modeling"

Showing result 1 - 5 of 7 essays containing the words in silico modeling.

  1. 1. Integration of Deep Brain Stimulation Modeling Tools

    University essay from Uppsala universitet/Institutionen för informationsteknologi

    Author : Lina Wilhelmina Sundqvist; [2023]
    Keywords : ;

    Abstract : Deep brain stimulation is a treatment in which neural targets are stimulated by electrical pulses delivered through implanted leads to alleviate symptoms in certain neurological- and psychiatric disorders. To achieve a beneficial clinical outcome, adjusting the stimulation parameters is a crucial step, which, at present, is a tedious and difficult trial-and-error procedure. READ MORE

  3. 2. Quantum Chemical Modelling for Predicting Mutagenicity

    University essay from KTH/Tillämpad fysikalisk kemi

    Author : Katarina Petrovic; [2021]
    Keywords : in silico; mutagenicity; Mutagen-X; LUMO; Ames test; in silico; mutagenicitet; Mutagen-X; LUMO; Ames test;

    Abstract : Mutageniciteten för olika ämnen bestäms vanligtvis med hjälp av konventionella in vivo och in vitro metoder. Att övergå till in silico metoder vore både etiskt och miljö- mässigt gynnsamt. Flera olika parametrar kan användas för att förutse mutagenicitet. READ MORE

  4. 3. Models for predicting efflux transport over the blood-brain barrier

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Marjaneh Janani; [2020]
    Keywords : Efflux; blood-brain-barrier; modeling; transporter;

    Abstract : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. READ MORE

  5. 4. Modelling conversion of adult skin cells to neurons

    University essay from Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

    Author : Viktor Drugge; [2018]
    Keywords : Human adult fibroblast; Neuron; Neural conversion; Transdifferentiation; Direct reprogramming; Direct lineage conversion; Simulation; Regulatory gene network; Gene network topology; Gene circuit; Gene dynamics; Physics and Astronomy;

    Abstract : Scientists are now able to directly convert one somatic cell type into another using a procedure known as direct lineage reprogramming or transdifferentiation. In this procedure, transcription factors which are important for initiating a rewriting of the gene expressions are introduced in the cell. READ MORE

  6. 5. Building predictive unbound brain-to-plasma concentration ratio (Kp,uu,brain) models

    University essay from Lunds universitet/Examensarbeten i bioinformatik

    Author : Srinidhi Varadharajan; [2014]
    Keywords : Biology and Life Sciences;

    Abstract : Abstract The blood-brain barrier (BBB) constitutes a dynamic membrane primarily evolved to protect the brain from exposure to harmful xenobiotics. The distribution of synthesized drugs across the blood-brain barrier (BBB) is a vital parameter to consider in drug discovery projects involving a central nervous system (CNS) target, since the molecules should be capable of crossing the major hurdle, BBB. READ MORE