Essays about: "intracellular target"

Showing result 1 - 5 of 8 essays containing the words intracellular target.

  1. 1. Investigating ERβ chromatin binding and its potential interaction with LRH-1 in an ovarian context

    University essay from KTH/Proteinvetenskap

    Author : Mick Phenphak; [2023]
    Keywords : estrogen receptor beta; ovary; granulosa cells; ChIP; qPCR; östrogen receptor beta; äggstock; granulosa celler; ChIP; qPCR;

    Abstract : Invasiv äggstockscancer anses vara en av de mest dödligaste gynekologiska maligniteterna. Granulosacelltumör i äggstocken är en sällsynt subtyp av äggstockstumör, som utgör 1–5% av alla äggstockstumörer. De kan kännetecknas av den långsamma tillväxthastigheten och produktionen av höga östrogennivåer. READ MORE

  3. 2. IL13R⍺2-CAR T cells for Immunotherapy of Glioblastoma

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Xu Zhu; [2021]
    Keywords : ;

    Abstract : Glioblastoma is the most malignant form of gliomas and is a highly infiltrative while non-metastatic tumor of the central nervous system. Patients with glioblastoma have a poor prognosis of 15 months median survival after diagnosis. READ MORE

  4. 3. Evaluation of mechanisms for accessing intracellular targets for protein-based drugs

    University essay from Uppsala universitet/Avdelningen för farmaceutisk biokemi

    Author : Sonav Jindi Elias; [2021]
    Keywords : intracellular target; neuronal uptake; biological drug; receptor mediated uptake; cell-penetrating peptides;

    Abstract : Over the years, biological drugs have evolved and have made breakthroughs in diseases associated with extracellular proteins. However, intracellular proteins that cause disease progression are still largely inaccessible. READ MORE

  5. 4. Towards Identifying Pharmacodynamic Blood Biomarkers of MAP3K12 Inhibition

    University essay from Lunds universitet/Tillämpad biokemi

    Author : Elisabeth Jirström; [2017]
    Keywords : Mitogen-activated protein kinase kinase kinase; MAP3K12; Amyotrophic lateral sclerosis; DLK; ALS; Pharmacodynamic; Biomarker; applied biochemistry; tillämpad biokemi; Technology and Engineering; Biology and Life Sciences; Medicine and Health Sciences; Chemistry;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons in the brain and spinal cord, for which there is no cure. Activation of the stress-induced c-Jun N-terminal kinase (JNK) signaling pathway, a critical mediator of neuronal apoptosis and axon degeneration, is evident in ALS and is therefore considered a potential target to prevent neurodegeneration. READ MORE

  6. 5. The role of FGFs in the elicitation of different cellular responses

    University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Author : Caroline Laestander; [2013]
    Keywords : FGF; fibroblast growth factor; FGF receptor; cellular effects diversity; cellular responses; proliferation; migration;

    Abstract : Fibroblast growth factors are signaling peptides that controls important cellular processes such as proliferation, differentiation, migration, adhesion and survival. Through binding to different types of receptors on the cell surface, these peptides can have different effect on the target cell. Which effect that is achieved depends on many factors. READ MORE