Essays about: "ion exchange chromatography"
Showing result 16 - 20 of 25 essays containing the words ion exchange chromatography.
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16. Model Calibration and Optimization of a Protein Purification Process
University essay from Lunds universitet/Kemiteknik (CI)Abstract : Four different chromatography models were calibrated to describe the separation of a ternary protein mixture consisting of lysozyme, cytochrome C and ribonuclease A in an ion-exchange chromatography column. The models are based on the same column model, the kinetic dispersive model. READ MORE
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17. Performance analysis of a PEGylation process -Process comparison of a tubular reactor with recirculation to a conventional batch reactor
University essay from Lunds universitet/Kemiteknik (CI)Abstract : Since the rise of therapeutical proteins, there has been a growing interest in biopharmaceuticals over the years. Research was made to combat various protein weaknesses like fast degradation and low solubility. A discovery in the 1970s suggested that an attachment of polyethylene glycol (PEG) on protein surfaces would solve the specific problems. READ MORE
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18. Optimization of a PEGylation process
University essay from Lunds universitet/Kemiteknik (CI)Abstract : The PEGylation process is a covalent attachment between a protein (the pharmaceutical) and poly ethylene glycol (PEG) and since the beginning in 1977 PEGylation processes have been used to improve pharmaceuticals. PEGylation of a pharmaceutical achieves improved properties like greater solubility in water, longer residence time in vivo and extended shelf life. READ MORE
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19. Modelling and simulation of antibody purification
University essay from Lunds universitet/Kemiska institutionen; Lunds universitet/Kemiteknik (CI)Abstract : Due to their high specificity against target antigens, monoclonal antibodies (mAbs) have proven to be a very powerful tool for diagnostic and therapeutic purpose against several diseases. Currently there are over 26 mAb approved for therapeutic use by the FDA. The manufacture of mAbs is a complex process where purification plays a key role. READ MORE
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20. Physical and functional properties of chromatography media : a down-scale study
University essay from Institutionen för biologisk grundutbildningAbstract : During down scale of column chromatography a phenomenon called wall effect appears.This supports the gel bed and gives it better flow properties. Using three different media infive different sized columns this effect was investigated regarding the physical andfunctional properties of the media. READ MORE
