Essays about: "irinotecan"

Found 3 essays containing the word irinotecan.

  1. 1. Lipodisks for Dual Delivery of SN-38 and Melittin

    University essay from Uppsala universitet/Institutionen för kemi - Ångström

    Author : Nathalie Alanko; [2022]
    Keywords : ;

    Abstract : The use of drug delivery systems based on liposomes or lipodisks as nanocarriers have been proven to have several advantages compared to conventional chemotherapy when drug is administered in free form. Lipodisks are not as well studied as liposomes, but can be reliably produced with a smaller size which is an important factor for efficient accumulation at the target site and penetration of tumor tissue. READ MORE

  3. 2. Screening of pancreatic cancer cell lines with oncolytic adenovirus Ad5ΔE1ACR2ΔE1B19k (Ad5ΔΔ) in combination with chemotherapeutics

    University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Author : Cecilia Kallin; [2009]
    Keywords : gene therapy; adenovirus; pancreatic cancer; oncolysis; chemotherapy;

    Abstract : Pancreatic cancer is one of the most aggressive and lethal forms of cancer, with high mortality and short survival. Chemotherapy using Gemcitabine is the most common treatment used but tumours frequently show resistance to the drug, necessitating the development of new and more potent therapy options. READ MORE

  4. 3. IRINOTECANTOXICITY RELATED TO GILBERT´S SYNDROME   - COMPARISON OF THREE METHODS FOR GENOTYPING OF UGT1A1 (TA)n

    University essay from Institutionen för medicinsk biokemi och mikrobiologi

    Author : Lena Fredriksson; [2009]
    Keywords : Fragment analysis; genetic analysis; Gilbert´s syndrome; irinotecan; TATA box; UDP Glucuronosyl-transferase 1A1; UGT1A1 *28;

    Abstract : Gilbert’s syndrome (GS) occurs in approximately 10% of the European population. The most common cause is homozygosity for UGT1A1*28, which is a TA repeat expansion in the promoter of UGT1A1. It is characterised by intermittent hyperbilirubinemia due to reduced hepatic activity of the  enzyme UDP-glucuronosyl-transferase 1A1(UGT1A1). READ MORE