Essays about: "liquid chromatography tandem mass spectrometry LC-MS MS"

Showing result 1 - 5 of 16 essays containing the words liquid chromatography tandem mass spectrometry LC-MS MS.

  1. 1. A Comparative Analysis of Per- andPolyfluoroalkyl Substances (PFAS) and ExtractableOrganofluorine (EOF) Using Solid PhaseExtraction-Weak Anion Exchange and Ion PairExtraction in SerumMarichal SalamehSpring 2021Independent project

    University essay from Örebro universitet/Institutionen för naturvetenskap och teknik

    Author : Marichal Salameh; [2021]
    Keywords : Extractable organofluorine EOF ; Per- and polyfluoroalkyl substances PFAS ; horse serum; human serum; ion pair extraction IPE ; solid phase extraction - weak anion exchange SPE-WAX ; liquid chromatography tandem mass spectrometry LC-MS MS ; combustion ion chromatography CIC ;

    Abstract : Per- and polyfluorinated substances (PFAS) are compounds that consist of a carbon chainbackbone that is partially or entirely fluorinated, with an addition of a functional group. SomePFAS are known as persistent organic pollutants (POPs) and have therefore been drawing a lot ofattention as well as increased concerns. READ MORE

  3. 2. Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma

    University essay from KTH/Tillämpad fysikalisk kemi

    Author : Leona Clarin; [2020]
    Keywords : Unbound concentration; free concentration; ultrafiltration; LC-MS MS; cefotaxime; flucloxacillin; cloxacillin; piperacillin; Fri fraktion; ultrafiltrering; LC-MS MS; cefotaxim; flukloxacillin; kloxacillin; piperacillin;

    Abstract : Infections in critically ill patients are a problem for the healthcare system and at any one time, 70 % of all intensive care unit (ICU) patients are treated with antibiotics. Antibiotics bind toproteins in the blood, but only unbound drug can diffuse over capillary membranes and bindto the targeted receptor. READ MORE

  4. 3. Identification of metabolite-protein interactions among enzymes of the Calvin Cycle in a CO2-fixing bacterium

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Emil Sporre; [2020]
    Keywords : Cupriavidus necator; chemolithoautotroph; limited proteolysis; Calvin Cycle; carbon fixation; proteomics; allosteric regulation; metabolite-protein interactions.;

    Abstract : The Calvin – Benson cycle is the most widespread metabolic pathway capable of fixing CO2 in nature and a target of very high interest to metabolic engineers worldwide. In this study, 12 metabolites (ATP, AMP, NADP, NADPH, 2PG, 3PGA, FBP, RuBP, PEP, AKG, Ac-CoA and phenylalanine) were tested for protein – metabolite interactions against the proteome of Cupriavidus necator (previously Ralstonia eutropha) in the hopes of finding potential examples of allosteric regulation of the Calvin – Benson cycle. READ MORE

  5. 4. Total oxidizable precursor assay: Applications and limitations. A study on the occurrence of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in Chinese Wastewater Treatment Plants

    University essay from Örebro universitet/Institutionen för naturvetenskap och teknik

    Author : Pontus Larsson; [2020]
    Keywords : ;

    Abstract : Total oxidizable precursor (TOP) assay is an in-lab method which oxidatively converts precursor compounds of poly- and perfluoroalkyl substances (PFASs) into measurable perfluorinated alkyl acids (PFAAs). The method is a very strong tool to semi-quantify PFASs that would otherwise be missed in conventional targeted analysis using liquid chromatography - tandem mass spectrometry (LC-MS/MS). READ MORE

  6. 5. Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Leona Clarin; [2020]
    Keywords : unbound; LC-MS MS; beta-lactam; antibiotics; ultrafiltration; proteinbindning; koncentration; antibiotika; beta-laktam; ultrafiltrering;

    Abstract : Kritiskt sjuka patienter med infektioner är en börda för sjukvården och 70 % av alla patienter på intensivvårdsavdelningar är ordinerade antibiotika. Antibiotika binder till proteiner i blodet, men enbart den icke-proteinbundna (fria) fraktionen kan diffundera över kapillära membran och binda till receptorer. READ MORE