Essays about: "mAbs"

Showing result 6 - 10 of 17 essays containing the word mAbs.

  1. 6. Development of a high-throughput platform for generation and early screening of high producing stable cell lines

    University essay from KTH/Proteinvetenskap

    Author : Jonathan Karlsson Persson; [2021]
    Keywords : CHO-K1; HEK293; CellCelector™; High-throughput screening; Protein A beads; Secondary antibody; CHO-K1; HEK293; CellCelector™; Högkapacitets-screening; Protein A-kulor; Sekundär antikropp;

    Abstract : Produktionen av rekombinanta biofarmaceutiska läkemedel, exempelvis monoklonala antikroppar, är en oumbärlig men ansträngande process. Under 2019 var sju av de tio mest sålda läkemedlen globalt baserade på rekombinant producerade monoklonala antikroppar. READ MORE

  3. 7. The art of making a comprehensive stability study

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Roman Lord; [2020]
    Keywords : Biopharmaceuticals; mAbs; SEC; stability study design; technical analytical chemistry; teknisk analytisk kemi; Technology and Engineering; Chemistry;

    Abstract : There is a need for harmonisation of stability study designs of monoclonal antibodies. Monoclonal antibodies (mAbs) are widely used in treatments for various diseases. Like all drugs, their quality must be verified through stability studies. READ MORE

  4. 8. A comparison of different orthogonal techniques for the investigation of the conformational stability of NIST mAb in liquid formulations

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Madeleine Andersson; [2020]
    Keywords : Pharmaceutical technology; Läkemedelsteknologi; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Abstract : A great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. READ MORE

  5. 9. Production and validation of anti-HCV antibodies for viral neutralization

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Megan Olga García Mark; [2020]
    Keywords : Cloning; antibody; infection; HCV; IgG production; molecular biology; cell factory; plasmid design; immunology;

    Abstract : Hepatitis-C Virus (HCV) remains the leading cause of liver transplant in the US and the UK, and the World Health Organization (WHO) estimates that 71 million people are infected worldwide. A vaccine would drastically impact the healthcare-associated burdens that HCV causes globally. READ MORE

  6. 10. Increased expression of therapeutic proteins by identification of 3'-UTRs from high expressing genes in CHO cells

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Alexander Westlund; [2019]
    Keywords : Mammalian cell; CHO; E. coli; protein expression; plasmid; transformation; Fc-fusion protein; flow cytometry; FACS; transfection; mRNA; UTR; gene engineering;

    Abstract : Therapeutic proteins, a.k.a. biopharmaceuticals, are most commonly produced in expression systems derived from Chinese Hamstery Ovary (CHO) cells, thanks to great capacity of post-translational modifications like secretation, folding and glycosylation. READ MORE