Essays about: "mitochondrial DNA"

Showing result 1 - 5 of 24 essays containing the words mitochondrial DNA.

  1. 1. Epigenetic Regulation of Mitochondrial DNA

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Jennie Johansson; [2020]
    Keywords : Acetylation; Epigenetics; Heteroplasmy; Methylation; Mitochondrial haplotype; Mitochondrion; Non coding RNA; Phosphorylation;

    Abstract : This mini-review investigates and compiles the latest knowledge regarding epigenetic changes on the mammalian mitochondrial DNA and its proteins. Methylation of the DNA, acetylation of the proteins and silencing of genes by short non-coding RNAs are the main epigenetic changes known today to affect mitochondrial DNA, mostly leading to repression. READ MORE

  2. 2. Optimization of a multiplex ARMS-PCR for detection of the primary mutations causing Leber’s hereditary optic neuropath

    University essay from Uppsala universitet/Institutionen för kvinnors och barns hälsa

    Author : Klara Jäder; [2020]
    Keywords : Allele-specific PCR; LHON; Multiplex Polymerase Chain Reaction; mitochondrial DNA; single nucleotide polymorphism;

    Abstract : Leber’s hereditary optic neuropathy (LHON) is a genetic disease that causes the patients to become blind, first in one eye and then the other, around the ages of 10-75 years. The disease is caused by mutations in the mitochondrial DNA, which disturbs the respiratory chain leading to the deterioration of the retinal ganglion cells. READ MORE

  3. 3. Optimization of a Multiplex PCR-RFLP Method Used for Detection of Three Primary Mutations in Leber’s Hereditary Optic Neuropathy Patients

    University essay from Uppsala universitet/Institutionen för kvinnors och barns hälsa

    Author : Emilia Nord; [2020]
    Keywords : LHON; Restriction enzyme; Multiplex PCR; Mutation detection; Mitochondrial mutation;

    Abstract : Leber’s hereditary optic neuropathy (LHON) is the most commonly inherited disease that causes blindness in one or both eyes, with a minimum prevalence of 1 in 31 000 in the northeast of England. What causes LHON is not fully known but three mitochondrial mutations, G3460A, G11778A, and T14484C, have been identified in over 95 % of all LHON patients. READ MORE

  4. 4. Identifying Mitochondrial Genomes in Draft Whole-Genome Shotgun Assemblies of Six Gymnosperm Species

    University essay from Stockholms universitet/Matematiska institutionen

    Author : Yrin Eldfjell; [2018]
    Keywords : machine-learning classification genome plant mitochondria svm contigs gymnosperm;

    Abstract : Sequencing efforts for gymnosperm genomes typically focus on nuclear and chloroplast DNA, with only three complete mitochondrial genomes published as of 2017. The availability of additional mitochondrial genomes would aid biological and evolutionary understanding of gymnosperms. Identifying mtDNA from existing whole genome sequencing (WGS) data (i. READ MORE

  5. 5. Genetic diversity of North Ethiopian indigenous sheep populations using mitochondrial DNA

    University essay from SLU/Dept. of Animal Breeding and Genetics

    Author : Mulata H. Adhena; [2018]
    Keywords : sheep; mitochondria; Ethiopia;

    Abstract : This study was aimed to investigate the haplotype variations and maternal origin of four sheep populations (Highland, Abergelle, Elle and Begait) of North Ethiopia. A 1088 bp of the mtDNA control region was amplified using specific primers and the polymerase chain reaction was performed. The PCR products were purified and sequenced. READ MORE