Essays about: "molecule chemistry"

Showing result 1 - 5 of 46 essays containing the words molecule chemistry.

  1. 1. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    University essay from Uppsala universitet/Analytisk kemi

    Author : Maryam Dost; [2024]
    Keywords : Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Abstract : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. READ MORE

  3. 2. A novel approach for functionalising and separating Tröger's Base Analogues

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Emil Jakobsson; [2023]
    Keywords : Tröger s Base; Synthesis; Chromatography; Supramolecular chemistry; Diastereomers; Organic chemistry; Chemistry;

    Abstract : Tröger’s Base (TB) is a bicyclic compound containing a methanodiazocine group between two aromatic rings. The methylene bridge forces the molecule to have a bent formation; thus, the aromatic rings are close to 90 degrees relative to each other, resulting in a rigid concave aromatic cavity. READ MORE

  4. 3. Biocatalysis in Pickering emulsions

    University essay from Lunds universitet/Bioteknik (master); Lunds universitet/Bioteknik (CI)

    Author : Christine Vera Isabel Schmidt; [2023]
    Keywords : Enzymes; Pickering emulsion; Amine Transaminases; Green Chemistry; Stereoselectivity; Biotechnology; Biology and Life Sciences;

    Abstract : Employing enzymes as catalysts in the production of chiral amines that are both used as building blocks and active pharmaceutical ingredients might be promising due to milder reaction conditions compared to non-biological catalysts, exclusion of heavy metals, high selectivity towards substrates and precision in chirality of the products. Transaminases are attractive for the use in this process. READ MORE

  5. 4. Structural and Functional Characterisation of the Human Mitochondrial Pyruvate Carrier

    University essay from Lunds universitet/Kemiska institutionen

    Author : Simon Gripvall; [2023]
    Keywords : biochemistry; complex; MPC; proteoliposomes; pyruvate; transport; Chemistry;

    Abstract : The metabolism of pyruvate in the cell is abnormally regulated in several human diseases, such as type-II diabetes, cancer and neurodegenerative disorders, in which the human mitochondrial pyruvate carrier (HuMPC) sits at a pivotal point. It transports pyruvate across the inner mitochondrial membrane and consists of two proteins, MPC1 and MPC2, and is a potential drug target against these diseases. READ MORE

  6. 5. The Synthesis and Development of Potential Small Molecule Splice Modifiers toward a central nervous system (CNS) target for the treatment of a genetic disease

    University essay from KTH/Kemiteknik

    Author : Flore Miomandre; [2023]
    Keywords : organic synthesis; medicinal chemistry; pharmaceutical candidate; small molecule; genetic disease; organisk syntes; läkemedelskemi; läkemedelskandidat; småmolekylär; genetisk sjukdom;

    Abstract : Behandling av sällsynta sjukdomar är en stående utmaning inom läkemedelskemi då mer än 400 miljoner människor lider av 7000 olika sällsynta sjukdomar där få godkända läkemedel finns tillgängliga. Fokus för detta arbete är att syntetisera läkemedelskandidater för en sällsynt och livslång form av epilepsi med frekventa och långvariga anfall. READ MORE