Essays about: "monoclonal antibody"

Showing result 1 - 5 of 46 essays containing the words monoclonal antibody.

  1. 1. Establishment and Characterisation of new Immunoreagents for diagnosis of Ovarian cancer

    University essay from

    Author : Fanny Carlsson; [2023-04-19T12:15:23Z 2023-04-19T12:15:23Z 2022 2023]
    Keywords : ovarian; cancer; monoclonal; antibodies; biomarkers; CARM1; PARPi; EZH2i;

    Abstract : Ovarian cancer is the most lethal of all gynaecological cancers and it is often diagnosedat an advanced stage due to diffuse and only mild symptoms at early stages.Early detection is crucial to increase survival but high-grade serous ovarian cancer(HGSOC) often presents non-specific symptoms, such as loss of appetite, bloating ofabdomen and tiredness. READ MORE

  3. 2. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Jonathan Efverström; [2023]
    Keywords : Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

    Abstract : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. READ MORE

  4. 3. Generation of a new ADAPT library for stability improvement

    University essay from KTH/Proteinvetenskap

    Author : Sumant Yogesh Salphale; [2023]
    Keywords : Phage display; CEACAM5; EpCAM; Trop2; ADAPT; ABD; protein engineering; cancer detection; Fag-display; CEACAM5; EpCAM; Trop2; ADAPT; ABD; proteinteknik; cancerdetektion;

    Abstract : Under senare år har målinriktad terapi varit ett växande område inom cancerterapi som en mer målinriktad behandling än kemoterapi. Dessa behandlingar baseras främst på antikroppsbaserade läkemedel som är ganska stora och komplexa, vilket ökar den totala kostnaden för behandlingen. READ MORE

  5. 4. Identification of Monoclonal Antibodies:Peptide Mass Fingerprinting (PMF) with Matrix Assisted Laser Desorption/Ionization (MALDI), Time of Flight (ToF), Mass Spectrometry (MS) and Protein Peptide Mapping (PPM) with Capillary Electrophoresis (CE)

    University essay from KTH/Proteinvetenskap

    Author : Sofia Bengtsson; [2023]
    Keywords : Monoclonal Antibodies mAbs ; Matrix-Assisted Laser Desorption Ionization Time-of Flight Mass Spectrometry MALDI-ToF-MS ; In Source-Decay ISD ; Capillary Gel Electrophoresis CGE ; Capillary Zone Electrophoresis CZE ; Monoklonala antikroppar mAbs ; Matrix-Assisted Laser Desorption Ionization Time-of Flight Mass Spectrometry MALDI-ToF-MS ; In Source-Decay ISD ; Kapillärgelelektrofores CGE ; Kapillärzonelektrofores CZE ;

    Abstract : Antalet monoklonala antikroppar som används i läkemedel ökar kraftigt. Dessa läkemedel är dyra och risken för förfalskning är stor. Behovet att utveckla en metod för snabb och precis identifiering av monoklonala antikroppar är därför brådskande. READ MORE

  6. 5. Improving antibody-based immunotherapy protocols in vitro : Study on optimization of antitumor immunity by antibody-dependent phagocytosis with the monoclonal antibody rituximab

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Giovanni Ferro; [2022]
    Keywords : ;

    Abstract : The monoclonal antibody Rituximab (RTX) has been widely and successfully used to treat non-Burkitt B cell lymphoma in human patients. The combination of immunotherapy with low-dose chemotherapy has increased the success of the treatment and translated into increased patients’ survival. READ MORE