Essays about: "mutational analysis"

Showing result 1 - 5 of 12 essays containing the words mutational analysis.

  1. 1. Determining the Acoustic Mobility of Breast Cancer Cells

    University essay from Lunds universitet/Avdelningen för Biomedicinsk teknik

    Author : Simon Olsson; [2022]
    Keywords : Technology and Engineering;

    Abstract : Breast cancer is one of the most common forms of cancer detected in women. Its heterogeneity and large mutational landscape requires treatment strategies which varies between patients. Triple negative breast cancer (TNBC) is a particularly aggressive subtype which 12-17 \% of breast cancer patient develop. READ MORE

  2. 2. A mixed clinicopathological and molecular proxy of homologous recombination deficiency in triple negative breast cancer

    University essay from Lunds universitet/Examensarbeten i bioinformatik

    Author : Elise Walford; [2021]
    Keywords : Biology and Life Sciences;

    Abstract : Clinical models are increasingly employed in medical science as either diagnostic or prognostic aids. Machine-learning methods are able to draw links in large data that can be used to predict patient risk and allow more informed decisions regarding treatment and medication intervention. READ MORE

  3. 3. Supervised Learning for Prediction of Tumour Mutational Burden

    University essay from KTH/Matematisk statistik

    Author : Joanna Hargell; [2021]
    Keywords : Supervised Learning; Tumour Mutational Burden; Generalized Linear Models; Decision trees; Support Vector Machines; statistik; tillämpad matematik; statistisk inlärning; mutationsbörda;

    Abstract : Tumour Mutational Burden is a promising biomarker to predict response to immunotherapy. In this thesis, statistical methods of supervised learning were used to predict TMB: GLM, Decision Trees and SVM. READ MORE

  4. 4. PREPARATION AND CHARACTERIZATION OF BOVINE MEAT AND MILK FACTOR VESICLES/PARTICLES & IDENTIFICATION OF MSBI1 REP INTERACTING PROTEINS

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Farhana Manzoor; [2020]
    Keywords : Bovine meat and milk factors; multiple sclerosis; immunoprecipitation co-immunoprecipitation; protein dimers; mass spectrometry; immunodetection; cesium chloride density gradient centrifugation; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; vesicle; particle; interaction partner; pull-down assay.;

    Abstract : Introduction: Bovine meat and milk factors (BMMF) frequently isolated from bovine meat and milk, are discussed as putative causative agents for breast, colon and possibly other cancers. The hypothesis was formulated based on earlier correlative studies indicating that BMMFs could indirectly trigger inflammation, accumulate mutational events via reactive oxygen and nitrogen species production which eventually provokes tumor formation. READ MORE

  5. 5. Protecting Privacy: Automatic Compression and Encryption of Next-Generation Sequencing Alignment Data

    University essay from Uppsala universitet/Experimentell och klinisk onkologi

    Author : Wiktor Gustafsson; [2019]
    Keywords : data protection; compression; encryption; genomic data; privacy; cancer; ngs; next-generation sequencing; AES; Zstandard; sequencing;

    Abstract : As the field of next-generation sequencing (NGS) matures and the technology grows more advanced, it is becoming an increasingly strong tool for solving various biological problems. Harvesting and analysing the full genomic sequence of an individual and comparing it to a reference genome can unravel information about detrimental mutations, in particular ones that give rise to diseases such as cancer. READ MORE