Essays about: "next generation sequencing NGS"
Showing result 6 - 10 of 30 essays containing the words next generation sequencing NGS.
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6. Validation of a Next Generation Sequencing based method for chimerism analysis in clinical practice
University essay from Uppsala universitet/Institutionen för medicinsk cellbiologiAbstract : Hematopoietic stem cell transplantation (HSCT) is used to treat patient with hematological diseases such as leukemia and genetic conditions such as sickle cell anemia. After HSCT the patients are supervised for signs of relapse of disease or rejection of transplanted cells. This is done by using chimerism analysis. READ MORE
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7. Evaluation and implementation of quality control parameters for genome-wide DNA methylome sequencing
University essay from Högskolan i Skövde/Institutionen för biovetenskapAbstract : Epigenomics is the study of modifications to the genetic material without changes to the DNA sequence, one such modification is methylation of nucleotides. DNA methylation is associated with gene regulation and is studied in a variety of fields such as cancer and ageing. READ MORE
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8. Filtering of Clinical NGS Data to Improve Low Allele Frequency Variant Calling
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Massive parallel sequencing (NGS) is useful in detecting and later classifying somatic driver mutations in cancer tumours. False-positive variants occur in the NGS workflow and they may be mistaken for low frequency somatic cancer mutations in a patient sample. READ MORE
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9. Pipeline for Next Generation Sequencing data of phage displayed libraries to support affinity ligand discovery
University essay from Uppsala universitet/Institutionen för immunologi, genetik och patologiAbstract : Affinity ligands are important molecules used in affinity chromatography for purification of significant substances from complex mixtures. To find affinity ligands specific to important target molecules could be a challenging process. Cytiva uses the powerful phage display technique to find new promising affinity ligands. READ MORE
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10. Implementing ExomeDepth with a variant filter as a CNV-calling tool for germline clinical diagnostic testing
University essay from Högskolan i Skövde/Institutionen för biovetenskapAbstract : Copy number variations (CNVs) cover approximately 4.9 - 9.5% of the human genome. CNVs are involved in both the development of disease and evolutionary adaptions. READ MORE