Essays about: "non-coding regions"

Showing result 1 - 5 of 10 essays containing the words non-coding regions.

  1. 1. Identification of de novo Transcription Factor Binding Motifs Created by Cancer-related Mutations

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Siqi Li; [2022]
    Keywords : transcription factor binding motifs; funMotifs; PCAWG; mutations; de novo motifs;

    Abstract : In many countries, cancer is one of the biggest threats for citizens’ health, especially among aged people. Genomic mutations play a crucial role in cancer cell development. In previous decades, cancer research has been mainly focused on mutations in coding regions. READ MORE

  2. 2. Building a genomic variant based prediction model for lung cancer toxicity

    University essay from KTH/Tillämpad fysik

    Author : Vincent Janvid; [2021]
    Keywords : cancer; bioinformatics; genomics; cancer; bioinformatik; genomik;

    Abstract : Since the completion of the the Human genome project in 2003, the evident complexity of our genome and its regulation has only grown. The idea that having sequenced the human genome would solve this mystery was quickly discarded. READ MORE

  3. 3. Non-coding constraint mutations impact the gene regulatory system in osteosarcoma

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi; Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Raphaela Pensch; [2021]
    Keywords : cancer; osteosarcoma; cancer genomics; evolutionary constraint; non-coding mutations; gene regulation;

    Abstract : The non-coding space makes up around 98 % of the genome, but cancer-driving mutations have so far mostly been discovered in protein-coding regions. The majority of somatic non-coding mutations are neutral passenger mutations and identifying non-coding mutations with driving roles in cancer poses a challenge. READ MORE

  4. 4. Analysis of differentially expressed genes (DEGs) in neuronal cells from the cerebral cortex of Alzheimer’s disease mouse model

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Elnaz Bakhtiyari; [2020]
    Keywords : ;

    Abstract : Alzheimer’s disease (AD) is an aging-related neurodegenerative disorder with large implications for society and individuals. AD is a multi-factor disorder, with these factors having a direct or indirect correlation with each other. READ MORE

  5. 5. A zebrafish-based system to study the impact of environmental factors in Inflammatory Bowel Disease (IBD)

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Mikaela Westling; [2020]
    Keywords : IBD; non-coding regions; zebrafish; in vivo; transgenic dual reporters; enhancer activity; polyfluoroalkyl substances; dietary sensors;

    Abstract : Inflammatory Bowel Disease (IBD) is a chronic disorder that affects millions of peopleworldwide. Although the etiology behind the disease is yet unknown, current theoriespropose a complex interplay between genetic susceptibility, exposure to environmentalfactors and exacerbated immune responses. READ MORE