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Showing result 1 - 5 of 12 essays matching the above criteria.

  1. 1. Investigation of the interaction of A-MYB and TCFL5 on pachytene PIWI-interacting RNA genes in two sub-species of mice, mus musculus musculus and mus musculus castaneus

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Most Shova Banu; [2023]
    Keywords : ;

    Abstract : Spermatogenesis is a complex process that involves the production of sperm cells from germ cells in order to transmit genetic information to progeny. The PIWI-interacting RNA (piRNA) is a non-coding small silencing RNA that guides the PIWI protein to silence target transposon transcripts to regulate the production of germ cells. READ MORE

  3. 2. Evolutionary conservation analysis of sequence variants underlying ecological adaptation in Atlantic herring

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Leyi Su; [2023]
    Keywords : Ecological adaptation; Evolutionary conservation; Atlantic herring;

    Abstract : The Atlantic herring (Clupea harengus) is a model organism for exploring the genetic basis of ecological adaptation on account of its large effective population size which greatly restrains the disturbance of genetic drift. In this project, I conducted an evolutionary conservation analysis of the Atlantic herring genome using conservation scores generated by phastCon, phyloP and GERP++ in order to study the sequence variants related to salinity or spawning-time adaptation in Atlantic herring. READ MORE

  4. 3. Identification of de novo Transcription Factor Binding Motifs Created by Cancer-related Mutations

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Siqi Li; [2022]
    Keywords : transcription factor binding motifs; funMotifs; PCAWG; mutations; de novo motifs;

    Abstract : In many countries, cancer is one of the biggest threats for citizens’ health, especially among aged people. Genomic mutations play a crucial role in cancer cell development. In previous decades, cancer research has been mainly focused on mutations in coding regions. READ MORE

  5. 4. Building a genomic variant based prediction model for lung cancer toxicity

    University essay from KTH/Tillämpad fysik

    Author : Vincent Janvid; [2021]
    Keywords : cancer; bioinformatics; genomics; cancer; bioinformatik; genomik;

    Abstract : Since the completion of the the Human genome project in 2003, the evident complexity of our genome and its regulation has only grown. The idea that having sequenced the human genome would solve this mystery was quickly discarded. READ MORE

  6. 5. Non-coding constraint mutations impact the gene regulatory system in osteosarcoma

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi; Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Raphaela Pensch; [2021]
    Keywords : cancer; osteosarcoma; cancer genomics; evolutionary constraint; non-coding mutations; gene regulation;

    Abstract : The non-coding space makes up around 98 % of the genome, but cancer-driving mutations have so far mostly been discovered in protein-coding regions. The majority of somatic non-coding mutations are neutral passenger mutations and identifying non-coding mutations with driving roles in cancer poses a challenge. READ MORE